OBM Transplantation

(ISSN 2577-5820)

OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.

OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.

We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor. 

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 7 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).

Free Publication in 2019
Current Issue: 2019  Archive: 2018 2017

Special Issue

Multiple Aspects of Transplant Tolerance – Mechanisms, Strategies, and Barriers

Submission Deadline: September 30, 2018 (Open)                Submit Now

Guest Editor

Jean Kwun, PhD
Assistant Professor of Surgery, Duke Transplant Center, Department of Surgery, Duke University Medical Center, 207 Research Dr, Jones 362, Durham, NC 27710, USA
E-Mail: jean.kwun@duke.edu
Website: https://surgery.duke.edu/faculty/jean-kwun-phd
Research Interests: heart transplantation, transplant tolerance, humoral tolerance to organ transplants, mechanisms of antibody-mediated rejection (AMR), establishing a conceptual basis that will translate into therapeutic intervention of AMR

About This Topic

The idea of immunological tolerance was developed from seminal works by Ray Owen, Sir F. MacFarlane Burnet, and Sir Peter Medawar in the mid-20th century. These findings drove transplantation research to identify mechanisms of immune tolerance. However, despite partial success, it was unable to stably induce tolerance in immunocompetent recipients. In the special issue, “Multiple Aspects of Transplant Tolerance”, we will provide a forum for presenting mechanisms, strategies, and challenges for promoting tolerance in transplantation. This will include description of cell populations plays a crucial role in tolerance as well as cell-based approaches (Treg, Mreg, DCreg, CD8 Treg, Tr1, and not excluding BM, apoptotic cell-based strategies), identification/validation of clinical tolerance strategy and biomarkers. Finally, we will also cover B cell immunobiology in transplantation and strategies for B cell and plasma cell tolerance. The special issue will also be open to any author, but mainly invited by guest editor. Each submission will be reviewed by at least two reviewers to ensure a very high quality of papers selected for the Special Issue.

Publication

Open Access Review

Benefits of Combined Liver Transplant: Protection or Tolerance?

Salim Hamdani, Daniel Azoulay
Received: April 18, 2019; Published: September 04, 2019; doi:10.21926/obm.transplant.1903084

Open Access Review

Induction of Tolerance towards Solid Organ Allografts Using Hematopoietic Cell Transplantation in Large Animal Models

Scott S. Graves, David W. Mathes, Rainer Storb
Received: November 23, 2018; Published: August 23, 2019; doi:10.21926/obm.transplant.1903080

Open Access Review

Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand?

Joachim Andrassy, Antje Habicht
Received: November 05, 2018; Published: June 27, 2019; doi:10.21926/obm.transplant.1902070

Open Access Review

Innate Immune Determinants of Graft-Versus-Host Disease and Bidirectional Immune Tolerance in Allogeneic Transplantation

Anouk A. J. Hamers, Sunil K. Joshi, Asha B. Pillai
Received: September 29, 2018; Published: January 31, 2019; doi:10.21926/obm.transplant.1901044

Open Access Review

Cell based Therapy in Transplantation

Yi-nan Guo, Michael Grzelak, Byoung Chol Oh
Received: October 10, 2018; Published: December 14, 2018; doi:10.21926/obm.transplant.1804031

Open Access Review

Allogeneic Hematopoietic Cell Therapies to Induce Tolerance in Kidney Transplantation

Yujie Wen, Anita Y. Chhabra, Joseph R. Leventhal, Suzanne T. Ildstad
Received: October 29, 2018; Published: November 21, 2018; doi:10.21926/obm.transplant.1804027

Open Access Review

The Concerted Action of Multiple Mechanisms to Induce and Sustain Transplant Tolerance

Sylvaine You, Lucienne Chatenoud
Received: September 25, 2018; Published: November 09, 2018; doi:10.21926/obm.transplant.1804025

Open Access Opinion

The Holy Grail to Clinical Transplant Tolerance Is Paved with HLA Epitopes

Rene J. Duquesnoy
Received: July 11, 2018; Published: September 6, 2018; doi:10.21926/obm.transplant.1803018

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