Welcome to the new academic journal OBM Hepatology and Gastroenterology. Recent progress in understanding liver, biliary, pancreatic and gastro-intestinal diseases and their treatments has been observed in the world. OBM Hepatology and Gastroenterology publishes interesting and informative reviews, original articles, and invaluable case reports in this area. We also publish basic research as well as clinical research.

Hepatitis A virus (HAV), HBV, HCV, HDV, and HEV are still a serious issue worldwide. Treatments on these viruses have recently improved. However, liver fibrosis, cirrhosis and hepatocellular carcinoma are still critical conditions. We focus on all of these liver diseases. We also focus on broad-spectrum of gastro-intestinal diseases in this journal.

Please accept our special thanks for choosing to publish in the OBM Hepatology and Gastroenterology. We are looking forward to your submissions for OBM Hepatology and Gastroenterology.

Indexing: DOAJ-Directory of Open Access Journals.

Archiving: full-text archived in CLOCKSS.

Free Publication in 2020

Open Access Review

Human Gut Microbiota: Friend or Foe?

Monika Pliszka, Leszek Szablewski
Received: March 06, 2020; Published: August 07, 2020; doi:10.21926/obm.hg.2003050

Abstract: The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Simila [...]

Open Access Review

Use of Organs from Hepatitis C Viremic Donors: Addressing the Needs of a Changing Waitlist and the Effect of a Public Health Crisis

Brett W. Sadowski, Coleman I. Smith
Received: May 14, 2020; Published: July 20, 2020; doi:10.21926/obm.hg.2003049

Abstract: The combination of broad screening initiatives and development of effective antiviral therapies have led to a revolution in the treatment of hepatitis C virus and has reduced the proportion of patients with the virus who develop a need for liver transplantation in favor of other etiologies, such as [...]

Open Access Original Research

Prevalence of Chronic Constipation and Irritable Bowel Syndrome, and their Overlap, among Female Undergraduate Students in Japan

Katsuhisa Omagari, Risa Kumamoto,Yuko Koyama, Masako Suzuta, Asami Taniguchi, Ayumi Fukuda, Momoe Iwami, Kazunori Koba, Asako Kawaguchi, and Kazunori Otsuka
Received: April 10, 2020; Published: May 19, 2020; doi:10.21926/obm.hg.2002048

Abstract: Chronic constipation and irritable bowel syndrome (IBS) are two of the most common functional gastrointestinal disorders, both of which negatively affect the quality of life of the patients. Since people may have co-existing symptoms of multiple disorders, chronic constipation and IBS with predomina [...]

Open Access Original Research

Association between Sleep Deprivation and Metformin Treatment on Pancreatic and Liver Function in Mice

Srinivasan Periasamy, Se-Ping Chien, Chen Hsu, Dur-Zong Hsu, Ming-Yie Liu
Received: March 10, 2020; Published: May 18, 2020; doi:10.21926/obm.hg.2002047

Abstract: Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hypergl [...]

Open Access Review

Can HCV Viremic Organs Be Used in Liver Transplantation to HCV Negative Recipients?

Haris Muhammad, Muhammad Baraa Hammami, Peng-Sheng Ting, Cem Simsek, Behnam Saberi, Ahmet Gurakar
Received: February 02, 2020; Published: April 24, 2020; doi:10.21926/obm.hg.2002046

Abstract: Liver transplantation has steadily increased worldwide resulting in a large number of patients on the waiting list. Due to the opioid epidemic in the US, the pool of Hepatitis C seropositive donors increased significantly in recent years. Direct acting antivirals played an instrumental role in makin [...]

Open Access Review

Low Prevalence of Spontaneous Bacterial Peritonitis in Ambulatory Asymptomatic Cirrhotic Patients: Consequences in Patients’ Care

Jean-François Cadranel, Jean-Baptiste Nousbaum
Received: August 21, 2019; Published: April 15, 2020; doi:10.21926/obm.hg.2002045

Abstract: The literature on the prevalence of spontaneous bacterial peritonitis (SBP) in cirrhotic outpatients who visited the hospital for therapeutic abdominal paracentesis was reviewed in order to assess the usefulness of urinary strips in this setting. The authors reviewed the studies published as peer-re [...]

Open Access Opinion

Vitamin D in Patients with Chronic Hepatitis C Virus Infection Receiving the Direct Antiviral Agents

Hsuan-Wei Chen, Hsuan-Hwai Lin, Yu-Lueng Shih, Tsai-Yuan Hsieh, Jung-Chun Lin
Received: February 23, 2020; Published: March 30, 2020; doi:10.21926/obm.hg.2001044

Open Access Comment

On the Pathogenesis of Crohn´s Disease

Tommy Sundqvist, Lars Stenhammar, Bo Tjellström, Karl-Eric Magnusson, Tore Midtvedt, Elisabeth Norin, Lotta Högberg
Received: February 07, 2020; Published: March 09, 2020; doi:10.21926/obm.hg.2001043

Open Access Review

Endoscopic Therapy for Recurrent Acute Pancreatitis

Pier Alberto Testoni, Sabrina Testoni
Received: October 17, 2019; Published: December 23, 2019; doi:10.21926/obm.hg.1904042

Abstract: Recurrent acute pancreatitis (RAP) is a clinical entity characterized by episodes of acute pancreatitis which occurs on more than one occasion. Recurrence of pancreatitis generally occurs in a setting of a normal anatomical and functional gland, however, a chronic disease at early stage may be found [...]

Open Access Original Research

The Daclatasvir/Asunaprevir/Beclabuvir Combination Therapy for Chronic Hepatitis C Patients Experiencing Failure of IFN-Free DAA-Based Therapies

Ken Sato, Atsushi Naganuma, Shuichi Saito, Yuichi Yamazaki, Takeshi Kobayashi, Hiroki Tojima, Norio Horiguchi, Satoru Kakizaki, Toshio Uraoka, Hiroshi Ohnishi, Hiroaki Okamoto
Received: September 29, 2019; Published: December 17, 2019; doi:10.21926/obm.hg.1904041

Abstract: Background: Daclatasvir/asunaprevir/beclabuvir (DCV/ASV/BCV) combination therapy had been available for the treatment of chronic hepatitis C patients with genotype 1 (CHG1) in Japan. Our aim was to report the efficacy and safety of DCV/ASV/BCV in patients experiencing treatment failure with interfer [...]

Open Access Case Report

Hypereosinophilia with Gastrointestinal Involvement: A Case Report

Mauro Turrin, Barbara Mariotti, Isabella Schiavon, Serena Battista
Received: September 29, 2019; Published: November 22, 2019; doi:10.21926/obm.hg.1904040

Abstract: Hypereosinophilic syndrome is currently defined by an absolute blood eosinophil count of more of 1500 cell per μL for more than 1 month and by multiorgan system infiltration. Eosinophilic colitis is an exceptionally rare inflammatory condition in which eosinophils infiltrate the colonic gut. It repr [...]

Open Access Review

Platelet Function in Experimental Models of Liver Cirrhosis

Paola Romecín, Joaquín García-Estañ, Noemí M. Atucha
Received: May 15, 2019; Published: November 01, 2019; doi:10.21926/obm.hg.1904039

Abstract: (1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of f [...]

Open Access Case Report

Primary Pancreatic-Type Acinar Cell Carcinoma of Jejunum Arising from Ectopic Pancreas with Synchronous Metastasis to Left Adrenal Gland

Oliver H. Wang, Priya R. Bhosale, Jeannelyn S. Estrella
Received: July 08, 2019; Published: October 28, 2019; doi:10.21926/obm.hg.1904038

Abstract: Background: Pure pancreatic-type ACC outside the pancreas is extremely rare. Methods: We presented a very rare case of primary ACC of the pancreatic-type involving jejunum with a synchronous metastasis to left adrenal gland arising in well-developed ectopic pancreas which had fully developed pancre [...]

Open Access Case Report

Partial Response of Alopecia Areata to Helicobacter Pylori Eradication and Treatment with Low-Dose Naltrexone

Laura Alonso Canal, María José Quiles Blanco, David Jiménez Leiva, María José González Iglesias
Received: June 26, 2019; Published: September 30, 2019; doi:10.21926/obm.hg.1903037

Abstract: Alopecia areata is an autoimmune disease of unknown origin. It has been proposed that it is a multifactorial disease with genetic, immunological, infectious, circulatory, and psychogenic factors being involved in its etiopathogenesis. Its association with other autoimmune diseases is frequent. The i [...]

Open Access Perspective

Missing the Target to Treat in Crohn’s Disease

Herbert Van Kruiningen
Received: April 05, 2019; Published: September 30, 2019; doi:10.21926/obm.hg.1903036

Open Access Case Report

Secondary Acute Pancreatitis Associated with Paracetamol and Codeine Administration after Dental Treatment: Literature Analysis and Clinical Case Study

Alessandro Luigi Rossi, Vincenzo Capilupi, David Palombo, Luigi Tagliatesta, Tecla Terenzio, Marco Vitali, Matteo Chiapasco
Received: April 29, 2019; Published: August 30, 2019; doi:10.21926/obm.hg.1903035

Abstract: OBJECTIVES To review current literature analysing possible secondary complications in response to the administration of paracetamol and codeine as analgesics in the dental field. To discuss a case of secondary acute pancreatitis triggered by the administration of both active ingredients. MATERIALS A [...]

Open Access Review

Rare Causes of Acute Pancreatitis: Drugs, Eosinophilia, and Autoimmunity

Mauro Turrin
Received: March 15, 2019; Published: August 29, 2019; doi:10.21926/obm.hg.1903034

Abstract: Background: Among the rarest causes of acute pancreatitis, in addition to the drugs (DIAP), there are eosinophilic pancreatitis (EP) and autoimmune pancreatitis (AIP). Methods: we have researched on PUBMED the descriptions of clinical cases of eosinophilic pancreatitis appeared from 1990 to February [...]

Open Access Review

Advanced Endoscopic Techniques in the Evaluation and Treatment of Fibrostenotic Crohn's Disease

Alina Wong, Scott D Lee
Received: May 09, 2019; Published: August 16, 2019; doi:10.21926/obm.hg.1903033

Abstract: Crohn’s disease is characterized by chronic intestinal inflammation that can result in significant morbidity and loss of intestinal function over time. Many novel treatments for Crohn’s disease are being developed, but a significant portion of patients still requires surgical therapy for structuring [...]

Open Access Review

Conventional and Future Therapies for Crohn's Disease

Abdulmaleek Sado, Rahul Kalla, Simon Campbell
Received: May 20, 2019; Published: August 14, 2019; doi:10.21926/obm.hg.1903032

Abstract: Crohn's disease is part of a group of diseases termed inflammatory bowel disease. Guidelines have long advocated the use of steroids for acute flare up and Current goals of treatment include enhancing long-lasting remission, preventing relapse, reducing the need for surgery, preventing complications [...]

Open Access Review

New and Old Therapeutic Options for Luminal Crohn's Disease - An Overview of Current Literature

Rachel Rutherford, Patrick B Allen
Received: February 25, 2019; Published: August 12, 2019; doi:10.21926/obm.hg.1903031

Abstract: Crohn's Disease (CD) is a chronic inflammatory, relapsing and remitting condition that leads to structural damage of the bowel wall. It can be located in any part of the gastrointestinal tract with associated extra-intestinal manifestations. It varies in severity having many complications resulting [...]

Open Access Review

Pathological Angiogenesis: The New Culprit behind Chronic Liver Disease

Marta Ramirez, Mercedes Fernandez
Received: February 25, 2019; Published: July 31, 2019; doi:10.21926/obm.hg.1903030

Abstract: This review describes our current understanding of the pathogenic role of angiogenesis in chronic liver disease and portal hypertension, emphasizing its involvement not only in the liver but also in extrahepatic complications such as the formation of portosystemic collaterals and increased splanchni [...]

Open Access Review

Pancreatitis in Solid Organ Transplant Patients: A Review of the Literature

Danielle Graham, Takahiro Ito, Ronald Busuttil, Fady Kaldas
Received: May 05, 2019; Published: July 29, 2019; doi:10.21926/obm.hg.1903029

Abstract: Acute pancreatitis is a highly morbid condition widely recognized and well-defined in the general population. In this article, we summarize the current literature on acute pancreatitis in the setting of solid organ transplant axiom, including patients who are listed for or have undergone transplanta [...]

Open Access Review

Hereditary Pancreatitis – A Review of Current Concepts and Management

Daniel Hughes, Alex Gordon-Weeks, Michael A Silva
Received: April 30, 2019; Published: July 19, 2019; doi:10.21926/obm.hg.1903028

Abstract: (1) Background: Hereditary Pancreatitis is a rare cause of acute pancreatitis. These patients usually present at a young age with recurrent episodes of acute pancreatitis that usually progresses to chronic pancreatitis with associated endocrine and exocrine failure. Hereditary pancreatitis also ca [...]

Open Access Review

Therapeutic Strategies and Current Management for Hepatic Encephalopathy in Liver Cirrhosis

Kazuyuki Suzuki, Akinobu Kato, Yasuhiro Takikawa
Received: February 04, 2019; Published: July 16, 2019; doi:10.21926/obm.hg.1903027

Abstract: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome showing a wide spectrum and one of the serious complications seen in patients with acute and chronic liver disease or spontaneous portal-systemic shunting. Recently, HE has been classified into two categories: covert HE, which involves minim [...]

Open Access Review

Review of Current Evidence in Acute Pancreatitis

Samantha Varley, Kirsten Rossi, Meghan Murray, Alissa Nichole
Received: May 17, 2019; Published: July 12, 2019; doi:10.21926/obm.hg.1903026

Abstract: Acute pancreatitis (AP) is an inflammatory condition of the pancreas and is one of the most common ailments of the gastrointestinal system that results in significant morbidity and mortality. The main etiologic causes of AP are alcohol consumption, gallstones, hypertriglyceridemia, and biliary stone [...]

OBM Hepatology and Gastroenterology welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

Register and Submit now.