Table of Content

Open Access Original Research

Prevalence of Chronic Constipation and Irritable Bowel Syndrome, and their Overlap, among Female Undergraduate Students in Japan

Katsuhisa Omagari, Risa Kumamoto,Yuko Koyama, Masako Suzuta, Asami Taniguchi, Ayumi Fukuda, Momoe Iwami, Kazunori Koba, Asako Kawaguchi, and Kazunori Otsuka
Received: April 10, 2020; Published: May 19, 2020; doi:10.21926/obm.hg.2002048

Abstract: Chronic constipation and irritable bowel syndrome (IBS) are two of the most common functional gastrointestinal disorders, both of which negatively affect the quality of life of the patients. Since people may have co-existing symptoms of multiple disorders, chronic constipation and IBS with predomina [...]

30 261

Open Access Original Research

Association between Sleep Deprivation and Metformin Treatment on Pancreatic and Liver Function in Mice

Srinivasan Periasamy, Se-Ping Chien, Chen Hsu, Dur-Zong Hsu, Ming-Yie Liu
Received: March 10, 2020; Published: May 18, 2020; doi:10.21926/obm.hg.2002047

Abstract: Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hypergl [...]

26 230

Open Access Review

Can HCV Viremic Organs Be Used in Liver Transplantation to HCV Negative Recipients?

Haris Muhammad, Muhammad Baraa Hammami, Peng-Sheng Ting, Cem Simsek, Behnam Saberi, Ahmet Gurakar
Received: February 02, 2020; Published: April 24, 2020; doi:10.21926/obm.hg.2002046

Abstract: Liver transplantation has steadily increased worldwide resulting in a large number of patients on the waiting list. Due to the opioid epidemic in the US, the pool of Hepatitis C seropositive donors increased significantly in recent years. Direct acting antivirals played an instrumental role in makin [...]

46 277

Open Access Review

Low Prevalence of Spontaneous Bacterial Peritonitis in Ambulatory Asymptomatic Cirrhotic Patients: Consequences in Patients’ Care

Jean-François Cadranel, Jean-Baptiste Nousbaum
Received: August 21, 2019; Published: April 15, 2020; doi:10.21926/obm.hg.2002045

Abstract: The literature on the prevalence of spontaneous bacterial peritonitis (SBP) in cirrhotic outpatients who visited the hospital for therapeutic abdominal paracentesis was reviewed in order to assess the usefulness of urinary strips in this setting. The authors reviewed the studies published as peer-re [...]

28 269

Open Access Opinion

Vitamin D in Patients with Chronic Hepatitis C Virus Infection Receiving the Direct Antiviral Agents

Hsuan-Wei Chen, Hsuan-Hwai Lin, Yu-Lueng Shih, Tsai-Yuan Hsieh, Jung-Chun Lin
Received: February 23, 2020; Published: March 30, 2020; doi:10.21926/obm.hg.2001044

46 313

Open Access Comment

On the Pathogenesis of Crohn´s Disease

Tommy Sundqvist, Lars Stenhammar, Bo Tjellström, Karl-Eric Magnusson, Tore Midtvedt, Elisabeth Norin, Lotta Högberg
Received: February 07, 2020; Published: March 09, 2020; doi:10.21926/obm.hg.2001043

57 429

Open Access Review

Endoscopic Therapy for Recurrent Acute Pancreatitis

Pier Alberto Testoni, Sabrina Testoni
Received: October 17, 2019; Published: December 23, 2019; doi:10.21926/obm.hg.1904042

Abstract: Recurrent acute pancreatitis (RAP) is a clinical entity characterized by episodes of acute pancreatitis which occurs on more than one occasion. Recurrence of pancreatitis generally occurs in a setting of a normal anatomical and functional gland, however, a chronic disease at early stage may be found [...]

55 581

Open Access Original Research

The Daclatasvir/Asunaprevir/Beclabuvir Combination Therapy for Chronic Hepatitis C Patients Experiencing Failure of IFN-Free DAA-Based Therapies

Ken Sato, Atsushi Naganuma, Shuichi Saito, Yuichi Yamazaki, Takeshi Kobayashi, Hiroki Tojima, Norio Horiguchi, Satoru Kakizaki, Toshio Uraoka, Hiroshi Ohnishi, Hiroaki Okamoto
Received: September 29, 2019; Published: December 17, 2019; doi:10.21926/obm.hg.1904041

Abstract: Background: Daclatasvir/asunaprevir/beclabuvir (DCV/ASV/BCV) combination therapy had been available for the treatment of chronic hepatitis C patients with genotype 1 (CHG1) in Japan. Our aim was to report the efficacy and safety of DCV/ASV/BCV in patients experiencing treatment failure with interfer [...]

63 683

Open Access Case Report

Hypereosinophilia with Gastrointestinal Involvement: A Case Report

Mauro Turrin, Barbara Mariotti, Isabella Schiavon, Serena Battista
Received: September 29, 2019; Published: November 22, 2019; doi:10.21926/obm.hg.1904040

Abstract: Hypereosinophilic syndrome is currently defined by an absolute blood eosinophil count of more of 1500 cell per μL for more than 1 month and by multiorgan system infiltration. Eosinophilic colitis is an exceptionally rare inflammatory condition in which eosinophils infiltrate the colonic gut. It repr [...]

84 683

Open Access Review

Platelet Function in Experimental Models of Liver Cirrhosis

Paola Romecín, Joaquín García-Estañ, Noemí M. Atucha
Received: May 15, 2019; Published: November 01, 2019; doi:10.21926/obm.hg.1904039

Abstract: (1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of f [...]

78 754