Journal Flyer

Current Issue 2018  Archive 2017 
Biography
Biography

Editor-in-Chief of OBM Hepatology and Gastroenterology

Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.

Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.

Biography

The Associate Editor of OBM Hepatology and Gastroenterology

Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.

Special Issue

Treatment of Genetic Disease

Submission Deadline: June 30, 2018 (Open)                Submit Now

Guest Editor

Khue Vu Nguyen, PhD, DSc
Full Project Scientist, Departments of Medicine and Pediatrics, University of California of San Diego, San Diego, USA
E-Mail: [email protected]
Research Interests: molecular biology; genetic diseases; enzymology; biosensors; biopolymers; neurodevelopmental and neurodegenerative disorders; cancer

About This Topic

It is with great pleasure to introduce a special issue, namely “Treatment of Genetic Disease”, which is scheduled to appear this year in OBM Genetics. I cordially invite authors to contribute their excellent works to this exciting forum. Submissions are now open and will be fully considered for publication.

Genes are the building blocks of heredity. They are passed from parent to child. A genetic disease occurs when a person has one or more abnormal genes, missing genes, extra genes, inactivated genes, or overly active genes that lead to a medical condition. With the increasing ability to control infectious and nutritional diseases in developed countries, there has come the realization that genetic diseases are a major cause of disability, death, and human tragedy. Recent findings, however, show a role of epigenetic modifications, gene-gene and/or gene-environment interactions in the disease etiology. As such, in this special issue of OBM Genetics, I have selected topics that highlight the current progress in diagnostics and treatment of genetic diseases including gene, stem cell, epigenetic therapies, and discussed about future directions in the field aimed toward innovative therapies using RNA-based therapeutic or RNA as therapeutic target. To this end, specific mRNA in cells and tissues appears as an ideal target for therapeutic intervention and antisense drugs are potential treatment.

Planned Papers

Title: Mitochondrial replacement therapy in reproduction
Author: Joep Geraedts
Affiliation: Emeritus Professor of Genetics and Cell Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, the Netherlands

Title: Treatment of Childhood Polycystic Kidney Disease
Author: Ellis Avner, Ameya Patil, William E. Sweeney
Affiliation: Emeritus Professor of Pediatrics and Physiology, Medical College of Wisconsin, Children's Research Institute; Children's Hospital Health System of Wisconsin, Milwaukee, WI, USA

Title: Experimental Therapies for Trinucleotide Repeat Diseases
Author: Inês Lopes Cardoso
Affiliation: Associate Professor at Fernando Pessoa University. Porto, Portugal

Title: Prospects of Curative Therapy for Wilson Disease
Author: Michelle Camarata1, Uyen To2, Michael L. Schilsky3
Affiliation: 1. Research Associate and Senior Fellow, Yale University and Royal Surrey Hospital, USA
2. Fellow in Transplant Hepatology, Yale University, USA
3. Professor of Medicine and Surgery, Yale University, USA

Publication

Editorial

Special Issue: Treatment of Genetic Disease

Khue Vu Nguyen
Received: January 19, 2018; Published: February 1,2018; doi:10.21926/obm.genet.1801012