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Editor-in-Chief of OBM Hepatology and Gastroenterology

Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.

Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.


The Associate Editor of OBM Hepatology and Gastroenterology

Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.

Special Issue

On the Role of Early-life Neuroinflammation in Neuropsychiatric Disorders

Submission Deadline: December 30, 2018 (Open)               Submit Now

Guest Editor

Jenny Berrío, MD, MSc
PPG-Ciências da reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245, Porto Alegre, Brazil
E-Mail: [email protected]
Research Interests: Behavior; Cognition: Models, animal, Neurodegenerative diseases; Neuronal plasticity; neuro-immune interactions


Bart Ellenbroek, PhD
Professor and Deputy Head of School, School of Psychology, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand
E-Mail: [email protected]
Research Interests: animal models; schizophrenia; gene-environment interactions; drug addiction; autism; dopamine; serotonin; behavior

About This Topic

Immune homeostasis within the brain is of special importance for its adequate functioning, thus not surprisingly, any breach of this balance can lead to impaired brain activity. Recent research has identified dysregulated neuroinflammation as a contributing factor in the vulnerability to and development of several neuropsychiatric disorders. In addition to autism and schizophrenia, anxiety and depression, as well as dementia, have now been linked to excessive inflammation of the brain. Particularly, an inappropriate inflammatory response during early-life has been consistently associated with an elevated susceptibility. It has long been known that early-life experiences have the capacity to alter brain development. By changing the long-term function of the immune system, which in turn influences brain function, early-life events have the potential to modify, in the long-term, how the brain is shaped and how it responds to other environmental challenges. The aim of this special issue is to publish up-to-date scientific literature on the topic, deepening the understanding of the complex mechanisms through which this brain-immune connection stresses out our mental health. Original research reports, review articles, communications, and perspectives are welcome in all areas pertinent to the topic. All accepted papers will be published totally free of charge.

Planned Papers

Title: Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction
Authors: Gina Sizemore1, Brandon Lucke-Wold2, Charles Rosen2, James W. Simpkins3, Sanjay Bhatia2, Dandan Sun4
1.Department of Clinical and Translational Science, West Virginia School of Medicine, Morgantown, WV
2.Department of Neurosurgery, West Virginia School of Medicine, Morgantown, WV
3.Center for Basic and Translational Stroke Research, West Virginia School of Medicine, Morgantown, WV
4.Department of Neurology, University of Pittsburgh, Pittsburgh, PA