Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.
Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.
Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.
Ovarian Development and Differentiation
Submission Deadline: December 31, 2018 (Open) Submit Now
Sergei G. Tevosian, PhD
About This Topic
The beginning of this century saw an unprecedented leap in our understanding of the mechanisms guiding mammalian female sexual determination as well as development, differentiation and function of the mammalian ovary. When an amazing flurry of research papers during that time were reviewed just six years ago, it appeared that a progress in this field would be worth revisiting on a yearly basis. Unfortunately, these predictions were based merely on the extraordinary advancement of research and the scientific merit of the discoveries. Fundamental science requires substantial financial support that notably decreased during the present decade, at least in the United States. However, despite these difficult times, even at a slower pace, many important developments enhanced our knowledge of ovarian differentiation and provided new important concepts and insight that, we feel, is now worth revisiting and appraising.
This issue of OBM Genetics attempts to integrate the recent work on the differentiation of the mammalian ovary. The major function of the ovary is the organization and coordination of the female germ cell differentiation. During fetal development, female germ cells switch from proliferation to meiosis before forming follicles. In the adult, the ovary stores and releases mature oocytes into the oviduct. We intend to cover a wide variety of topics including granulosa cell proliferation and survival, meiotic progression, follicle formation, assembly and growth, ovarian vascularization, steroid hormone production, and corpora luteal function. We will also review recent progress in understanding the contribution of epigenetic mechanisms to ovarian cell differentiation. Epigenetic mechanisms are important since gametes and developing embryos are sensitive to environmental factors during the critical period of gamete reprogramming. Adverse epigenetic modifications could have harmful impact on pregnancy outcomes and health of the offspring, and can be inherited over several generations. Genetic and epigenetic disorders in the somatic or germ cell development can result in abnormal folliculogenesis, reduced fertility and primary ovarian insufficiency.