OBM Transplantation

Special Issue

Antibody Mediated Rejection in Organ Transplantation

Submission Deadline: September 30, 2019(Open)               Submit Now

Guest Editor

Ignatius Tang, MD, PharmD, FASN, FAST, FACP
Associate Professor of Clinical Medicine, Medical Director, Kidney, Pancreas and Islet Transplant Programs, Director, Live Donor Kidney Transplant Program, Section of Nephrology, Department of Medicine, University of Illinois Medical Center at Chicago, 820 South Wood Street, M/C 793, Chicago, IL 60612, USA
E-Mail: [email protected]
Website: https://hospital.uillinois.edu/find-a-doctor/ignatius-y-tang
Research Interests: Antibody-mediated syndromes (antibody-mediated rejection, accommodation, transplant glomerulopathy); BK viral kinetics and immunosuppression; outcomes of obese kidney transplant recepients

About This Topic

Organ transplantation is a curative therapy for hundreds of thousands of patients with end-stage organ failure. However, long-term outcomes have not improved, and nearly half of transplant recipients will lose their allografts by 10 years after transplant. One of the major challenges facing clinical transplantation is antibody-mediated rejection (AMR) caused by anti-donor HLA antibodies.
Antibody mediated rejection (AMR) poses a significant and continued challenge for long term graft survival in organ transplantation. However, in the recent years, there has emerged an increased understanding of the varied manifestations of the antibody mediated processes in organ transplantation.
This special issue aims to describe the clinical and histological manifestations of AMR, and discusses the immunopathological mechanisms contributing to antibody-mediated allograft injury as well as current and emerging therapies.