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Editor-in-Chief of OBM Hepatology and Gastroenterology

Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.

Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.


The Associate Editor of OBM Hepatology and Gastroenterology

Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.

Special Issue

Tumors of the Central Nervous System

Submission Deadline: October 15th, 2018 (Open)               Submit Now

Guest Editor

Antonio Meola M.D. Ph.D
Clinical Instructor in Neurosurgery, Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Bldg. 94304, Stanford, CA
E-Mail: [email protected]
Research Interests: Brain Tumors, Skull Base Surgery, Image-guided Neurosurgery, Radiosurgery

About This Topic

The WHO classification of Tumors of the Central Nervous System (CNS) highlighted the pivotal role of molecular and genetic markers for predicting tumor biological behavior, therapy response and patient prognosis. We seek original research articles focusing on genetic, molecular and radiological features of CNS tumors that might impact on clinical practice, including clinical and preclinical data. Additionally, we invite submission of reviews, editorials, case reports, technical reports elucidating biological features of the CNS tumors, the interaction of tumors with healthy nervous tissue, as well as illustrating the effect of medications and cutting-edge technology on CNS tumor diagnosis and treatment.

Planned Papers

Title: Current Clinical Challenges in High Grade Meningioma
Authors: Blair Murphy, Jerry Jaboin
Affiliation: Knight Cancer Center, Oregon Health & Science University, Portland, Oregon, USA

Title: Effect of Tumoral Edema on Corticospinal Tractography: Changes After Surgical Removal
Authors: Ros de San Pedro. J, Cuartero Pérez. B
Affiliation: Regional Service of Neurosurgery, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar (Murcia), Spain.

Title: Diffuse Intrinsic Pontine Gliomas: Translation of Genomic Knowledge to Clinical Practice
Authors: Tina Zhou1, Sara Khan1,2,3,4, Ron Firestein1,2, Peter Downie3,4, Jason E Cain1,2
Affiliations: 1. Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia, 3168
2. Department of Molecular and Translational Medicine, School of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia, 3168
3. Monash Children’s Cancer Centre, Monash Children’s Hospital, Monash Health, Clayton, Victoria, Australia, 3168
4. Department of Paediatrics, Monash University, Clayton, Victoria, Australia, 3168

Title: Sporadic and hereditary hemangioblastoma: the role of endothelial cells
Authors: Alberto Feletti 1, Elena Bianchini 2, Anna De Gaetano 3, Lara Gibellini 2, Sara De Biasi 3, Giacomo Pavesi 1, Milena Nasi 2, Andrea Cossarizza 4, Marcello Pinti 3
1. Department of Neurosciences, Neurosurgery Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
2. Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy
3. Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy
4. Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

Title: Magnetic resonance imaging approaches for predicting the response to hyperoxic radiotherapy in glioma-bearing rats
Authors: Nuria Arias-Ramos 1, Jesus Pacheco-Torres 1, 2, Pilar López-Larrubia 1, *
1. Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, Madrid, Spain
2. Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Title: Indications for instrumented fusion during resection of intradural spinal cord tumors
Author: Michael Galgano
Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, New York, United States

Title: Angiocentric Glioma: A Review of Clinicopathologic Features
Authors: Richard A. Prayson
Affiliation: Department of Anatomic Pathology, Cleveland Clinic, United States

Title: Sphingosine-1-phosphate in glioblastomamultiforme: from basic science to the clinic
Author: Laura Riboni
Affiliation: Department of Medical Biotechnology and Translational Medicine, LITA-Segrate, University of Milan, Milan, Italy

Title: Breaking the barrier – towards winning the race to enhance glioblastoma immunotherapy
Authors: Ignacio Mastandrea 1, Liat Rousso-Noori 1 and Dinorah Friedmann-Morvinski 1, 2
1. Department of Biochemistry and Molecular Biology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
2. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel


Original Research

TTF-1-Expressing Supratentorial Embryonal Tumors (PNET): A Clinicopathologic Study of Two Cases and Literature Review of TTF-1-Positive Primary Brain Tumors

Michele Bisceglia, Stefano Pizzolitto, Tullio Parracino, Giovanna De Maglio, Elena Minenna, Serena D’Agostini, Carlos A. Galliani
Received: October 7, 2018; Published: November 14, 2018;  doi:10.21926/obm.neurobiol.1804016


Angiocentric Glioma: A Review of Clinicopathologic Features

Richard A. Prayson, MD, MEd
Received: September 4, 2018; Published: November 5, 2018; doi:10.21926/obm.neurobiol.1804015

Case Report

A Case Series of Temozolomide in the Management of Refractory Prolactinomas

Divya B. Mella, Josie Sewell, Edward Pan
Received: October 12, 2018; Published: October 31, 2018; doi:10.21926/obm.neurobiol.1804014

Research Article

Isolated Diffusion Restriction Preceding Contrast Enhancement in Glioblastoma Multiforme is Associated with Short-Term Survival

Jai Jai Shiva Shankar, Adil Bata, Namita Sinha
Received: August 7, 2018; Published: October 26, 2018; doi:10.21926/obm.neurobiol.1804013


Craniopharyngiomas: An Appropriate Surgical Treatment based on Topographical and Pathological Concepts

Ruth Prieto, José M Pascual
Received: September 11, 2018; Published: October 16, 2018; doi:10.21926/obm.neurobiol.1804012


Contribution of PET Imaging to Clinical Management of Gliomas

Wolf-Dieter Heiss
Received: July 2, 2018; Published: September 20, 2018; doi:10.21926/obm.neurobiol.1803011