Oxidative Stress and Inflammatory Responses in Neurodegenerative Diseases
Submission Deadline: March 15, 2019 (Open) Submit Now
Mohammad Moshahid Khan, PhD
Assistant Professor, Departments of Neurology and Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, United States
Email: [email protected]
Research Interests: Neuroscience; Pharmacology; Neurodegeneration; Neuroinflammation; Parkinson’s Disease; Stroke; Alzheimer’s Disease; Multiple Sclerosis and Traumatic Brain Injury
About This Topic
Inflammation and Oxidative stress are common features of chronic neurodegenerative diseases of the central nervous system. Chronic inflammation is characterized by longstanding microglial activation followed by sustained release of inflammatory mediators, which aid in enhanced nitrosative and oxidative stress. The sustained release of inflammatory mediators propels the inflammatory cycle by increased microglial activation, promoting their proliferation and thus stimulating enhanced release of inflammatory factors. Elevated levels of several cytokines and chronic neuroinflammation have been associated with many neurodegenerative disorders of central nervous system like age-related macular degeneration, Alzheimer disease, multiple sclerosis, Parkinson’s disease, Huntington’ disease, and tauopathies. In this special issue, we aim to the introduction of the relative research the basic mechanisms of neuroinflammation and oxidative stress, the characteristics of neurodegenerative diseases, and the main immunologic responses in CNS neurodegenerative disorders. Original research reports, review articles, communications, and perspectives are welcome in all areas pertinent to the topic. All accepted papers will be published totally free of charge.
Manuscripts should be submitted online at http://www.lidsen.com/account-login by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. Guidelines for authors and other relevant information for submission of manuscripts are available on the Instructions for Authors page. OBM Neurobiology is an international peer-reviewed Open Access monthly journal published by LIDSEN. Please visit the Instructions for Authors page before submitting a manuscript.
Neurodegenerative diseases; Inflammation; Oxidative stress; Cytokines and Inflammatory factors
Title: Characterisation of Oxidative Stress, Damage and Inflammation in a Cellular Model of Parkinson’s Disease
Authors: Wan T, Ishaq A, Khan A, Hunter C, Nagarathanam S, Morris J, Chan, M, Saretzki G*
Affiliation: The Ageing Biology Centre, Institute for Cell and Molecular Biosciences, Newcastle University
Title: Correlation Between Neuroimaging and Epigenetics in Chronic Discogenic Lumbar Pain
Authors: M.Marchesini 1, N. Peroni 2, M. Allegri 3
1. Pain Medicine Unit, ICS S. Maugeri Pavia, Italy
2. Anesthesia, Intensive Care Pain Medicine Department, San Matteo Pavia, Italy
3. Pain Therapy Service, Policlinico Monza Hospital, Monza Italy
Title: FT-IR studies on the influence of lead concentrations in serum on protein structure and oxidative stress in epileptic patients
Authors: J. Anastassopoulou 1, M. Kyriakidou 2, P. Nisianakis 3, G Papatheodorou 3, T. Theophanides 2, *
1. International Anticancer Research Institute, 1st km Kapandritiou-Kalamou Road, P.O. Box 22, Kapandriti, Attiki, 19014
2. National Technical University, Chemical Engineering School, Radiation Chemistry & Biospectroscopy, Zografou Campus, 15780
3. 401 Army General Hospital, Athens, Greece
Fourier transform infrared spectroscopy and ICP-MS elementary analysis were used to study the influence of lead serum levels on the life metal ions and protein secondary structure in epileptic patients. The ICP-MS elementary analysis showed considerable increase of the ratio, [Cu:Zn] by increasing the lead levels in blood serum, leading to oxidative stress. From serum infrared spectra it was observed that the band at 3290 cm-1, assigned to stretching vibration of vNH groups of proteins shifted to lower frequencies upon increasing the serum lead concentration, indicating changes of the molecular structure of proteins from amide A to amide B. The increase of the intensity band at 1744 cm-1, assigned to aldehyde bond, was related with the increasing of oxidative stress in the patients due to increasing lead concentration. From the shifts of the amide I and amide II bands from 1655 cm-1 and 1550 cm-1, respectively, to lower frequencies it is resulting the change of protein molecular structure from α-helix to random coil and to the protein amyloid formation. The band at about 1516 cm-1 is attributed to amyloid protein formation. An important change in the shape and slope of the bands in the spectral region between 1200-900 cm-1, where the phosphates and phosphate ribose groups of DNA absorb, suggested a DNA conformational change as a function of the increase of lead concentration.