Health Modifiers of Neurocognitive Aging
Submission Deadline: November 30, 2018 (Open) Submit Now
Kamen Tsvetanov, PhD
Centre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
E-Mail: [email protected]; [email protected]
Research Interests: Ageing; fMRI; neuroscience; connectomics; brain dynamics; cognitive neuroscience of ageing; relationship between human brain dynamics and cognition in healthy ageing and age-degenerative diseases
About This Topic
With the global demographic shift towards an older population, there is a pressing need to maintain mental wellbeing into late life, allowing people to work and live independently for longer. There are many influences on mental health which can be cultural, social, genetic, health and our own lifestyle decisions. These have an effect on our brain, and how well our brain works for what we call cognitive health – good memory, perception, language, judgement and so on.
The purpose of this Special Issue is to compile a number of selected research articles that focus on identifying factors for maintaining neurocognitive function across the lifespan – or ‘health modifiers’ – why some people seem to age without apparent adverse effects on their cognitive abilities, while others fare badly even without a dementia illness. In addition, this Special Issue welcomes review article submissions that critically assess the current knowledge on major health modifiers for mechanisms of neurocognitive aging. Addressing these issues has implications for understanding the influences that promote our brains process information to support mental functioning, throughout adult life.
Title: Physical Activity and Cognitive Improvement on the Mini-Mental State Examination (MMSE): A Meta-Analysis
Authors: Ilse Schuitema and Ioanna Gkika
Abstract: The current meta-analysis focused on the cognitive improvement following various physical activity-based intervention programs, as measured by the Mini-Mental State Examination (MMSE). The included population suffered from mild cognitive impairment, mild or moderate dementia, or Alzheimer’s Disease, indicated by MMSE scores of 20-25, 10-20 or 0-10 respectively. Searching online databases (PubMed, PsycInfo and Embase) yielded 11 relevant studies, while 4 more were retrieved through individual searching. Only 5 studies reported pre and post intervention MMSE scores. With Comprehensive Meta-Analysis Software (CMA), the random effects model was used to calculate the summary effect of the five different randomized controlled trials. We found statistically significant positive post-intervention changes, i.e. improvements on MMSE scores regarding general cognitive status (Hedges’g = 0.75, p = 0.034), with large heterogeneity between studies (I2 = 78.40). The results of the current meta-analysis confirmed the relationship between physical activity and cognitive improvement in people with cognitive impairment. Further research into the details of this relationship, as well as to the clinical implications of this relationship, is needed.
Title: Behavioral and complementary interventions for Healthy Neurocognitive Aging
Authors: Robert L Conder, Christopher Friesen, Alanna A. Conder
Title: Telomere-centric mechanism of chromosome number reduction in eukaryotes Authors: Zhenyi Wang, Xiyin Wang*