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Editor-in-Chief of OBM Hepatology and Gastroenterology

Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.

Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.


The Associate Editor of OBM Hepatology and Gastroenterology

Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.

Special Issue

Reproductive Genetics

Submission Deadline: April 30, 2018 (Open)               Submit Now

Guest Editors

Miodrag Stojkovic, PhD
Professor, Human Genetics, Faculty of Medical Sciences, University of Kragujevac, Spebo Medical, Leskovac, Serbia
E-Mail: [email protected]
Research Interests: embryology; stem cell biology; differentiation; regenerative medicine; reprogramming

Darren Griffin, PhD, DSc, FRSA, FRSB, FRCPath
Professor of Genetics, School of Biosciences, University of Kent, Director of the Centre for Interdisciplinary Studies of Reproduction (CISoR), Canterbury, Kent, CT2 7NJ, UK
E-Mail: [email protected]
Research Interests: genetics; chromosomes; cytogenetics; infertility; genome evolution

About This Topic

Reproductive health is a value for the community. Unfortunately, both female and male infertility is increasing in our societies and part of this is due to genetic factors. This leads to an increasing demand for access to reproductive counseling and assisted reproductive treatment (ART). In addition, as an important part of reproductive medicine, reproductive genetics focuses on reproductive options for couples with increased risks of transmitting genetic abnormalities and diseases. These include preimplantation genetic diagnosis and prenatal diagnosis.

Furthermore, reproductive genetics involves the more basic analysis of gametogenesis and the resulting oocytes, sperm cells, embryos and other reproductive tissues of mammalian and non-mammalian origin, including embryonic stem cells.

In this special issue of OBM Genetics we summarize the present knowledge and prospects of reproductive genetics through scientific and clinical activities with the aim to highlight key factors involved in early development and reproduction. With worldwide leaders in this rapidly increasing field, the special issue presents detailed picture of how reproductive genetics influences and assists biology of gametes and embryos, endometrial receptivity, fertility, ART and reproductive health. For sure, the issue is an essential guideline to understand basic mechanisms and improve medical treatments.

Planned Papers

Title: Unusual ways to lost Y chromosome and survive with changed autosomes: a story of mole voles Ellobius (Mammalia, Rodentia)
Authors: Irina Bakloushinskaya 1 and Sergey Matveevsky 2
1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow 119334, Russia; [email protected]
2. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, Russia; [email protected]
When does reproduction start? An old question of the chicken and the egg is even more complicated in relation to mole voles Ellobius. First, ‘chicken’ should be a female, and males are obviously involved in reproduction too because zygote is a result of sperm and oocyte fusion. But nobody knows how males appear in Ellobius lacking the Y chromosome (X0♂/X0♀ or XX♂/XX♀) and key testis-determining Sry gene. Second, it is unclear, how balanced gametes form in complex heterozygous hybrids, whose parents carry Robertsonian translocations with partial homology. Here we review studies of sex determination and meiotic mechanisms which evolved in mammals with the exceptional diversity of sex chromosomes and autosomes, mole voles Ellobius.

Title: On Objectivity in Prenatal Genetic Care
Authors: Diane B. Paul 1, 2, Lowy Ilana 3
Affiliations: 1. Professor Emerita, Department of Political Science, University of Massachusetts Boston; E-Mail: [email protected];
2. Associate in Zoology, Museum of Comparative Zoology, Harvard University, Cambridge, MA, USA
3. Centre de recherche médecine, sciences, santé, santé mentale, société - Cermes3, CNRS UMR 8211, Université Paris Descartes, Inserm U988, EHESS; E-Mail: [email protected]
We address an ongoing controversy over what health-care providers tell prospective parents about Down Syndrome (DS). In the view of critics, including many parent, disability-rights, and anti-abortion activists, the messages that health-care professionals transmit to pregnant women and their partners are distorted. OB-GYNs, primary-care providers, clinical geneticists, midwives and other medical professionals generally believe that the quality of life for individuals with DS and their families is poor. The critics maintain that, on the contrary, those with personal experience of DS are almost always satisfied with their lives. They believe that providers’ biases, directly or indirectly communicated to prospective parents, explain high rates of pregnancy termination for DS. If the information were unbiased, the argument goes, these rates would fall.
Objectivity in this context is assumed to mean the provision of information by those with experiential knowledge, who know what it is like to live with a particular condition. In practice, that means information prepared by organizations that advocate on behalf of affected individuals and their parents. But we argue that there is reason to be skeptical of the assumption that substituting the perspective of advocacy groups for those of medical professionals will realize the goal of achieving objectivity in prenatal care, and we suggest alternative strategies aimed at more effectively advancing that cause.