OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Indexing: DOAJ-Directory of Open Access Journals.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 8.5 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).

Current Issue: 2020  Archive: 2019 2018 2017

Special Issue

Pneumocystis: A Model of Adaptive Coevolution

Submission Deadline: October 31, 2018 (Open) Submit Now

Guest Editors

Andrés Moya

Prof. of Genetics, Institute of Integrative Systems Biology (University of Valencia), FISABIO Foundation for Biomedical Research and CIBER in Epidemiology and Public Health (CIBERESP), Spain

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Research Interests: genome evolution, symbiosis, microbiome

Enrique J.Calderón

Associate Prof. of Medicine, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, and Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain

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Research Interests: Infectious diseases, Pneumcystosis

Luis Delaye

Prof. of Bioinformatics, CINVESTAV Irapuato, México

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Research Interests: molecular evolution, phylogenetic inference

About This Topic

Pneumocystis organisms, which were first reported and named Pneumocystis carinii at the beginning of the last century, were long considered as protozoans and a single species based on morphologic features and the resistance to classical antifungal agents. The lack of a continuous in vitro system was a major obstacle to Pneumocystis research and these organisms were largely ignored until the dramatic increase in the incidence of Pneumocystis pneumonia that occurred with the emergence of the human immunodeficiency virus (HIV) pandemic, which made pneumocystosis a major medical and public health problem in the 1980s. However, this obvious pathogenic Pneumocystis–host interaction is only the tip of the iceberg, and recent findings suggest that the vast majority of mammal–Pneumocystis interactions led to relatively benign colonization, rather than pneumonia.

Molecular and biochemical studies have provided clear evidence for the placement of Pneumocystis with fungi, and based on genomic or phenotypic divergence, multiple Pneumocystis species have been recognized. Genetic data, in addition, suggested that speciation in the group resulted from long genetic isolation and co-evolution in parallel with mammal species.

In this special issue of OBM Genetics, we present the state-of-the art of the genetics and the coevolution of Pneumocystis in different mammalian species in a broad perspective, although with a particular emphasis on the human host. Reviews and methodological papers related with the topic are also welcome.

Planned Papers

Title: Dihydropteroate synthase (DHPS) polymorphisms in Pneumocystis jirovecii
Authors: Carmen de la Horra, Vicente Friaza, Rubén Morilla, María Mercedes Panizo, Yaxsier de Armas, Gustavo Wissmann, Enrique J. Calderón


Open Access Original Research

Genes Coding for GPI Biosynthesis in Pneumocystis Experienced Relaxed Selection: A Follow-up Study

Luis Delaye
Received: May 5, 2019; Published: July 11, 2019; doi:10.21926/obm.genet.1903083

Open Access Review

Airborne Interindividual Transmission of Pneumocystis jirovecii

Laurence Pougnet, Solène Le Gal, Gilles Nevez
Received: December 17, 2018; Published: May 22, 2019; doi:10.21926/obm.genet.1902080

Open Access Review

Pneumocystis Species Co-evolution: State-of-the-Art Review

Christine Demanche, Jacques Guillot, Magali Chabé
Received: February 22, 2019; Published: May 15, 2019; doi:10.21926/obm.genet.1902078

Open Access Research Article

New DNA Extraction Method for the Detection of Pneumocystis in Lung Tissue Samples of Colonized Individuals

Susana Ruiz-Ruiz, Carolina A Ponce, Nicole Pesantes, Rebeca Bustamante, Gianna Gatti, Viviana San Martin, Mireya Gutierrez, Mariana Izquierdo, Sergio L Vargas, Fabien Magne, Vicente Pérez-Brocal
Received: January 30, 2019; Published: March 18, 2019; doi:10.21926/obm.genet.1901066

Open Access Review

Genotyping Pneumocystis jirovecii: Impacting Our Understanding of Interhuman Transmission

Maud Gits-Muselli, Stéphane Bretagne, Alexandre Alanio
Received: December 4, 2018; Published: January 18, 2019; doi:10.21926/obm.genet.1901060

Open Access Review

Pneumocystis as a Co-Factor in Pulmonary Diseases

Whitney Rabacal, Emily Rayens, Karen Norris
Received: November 2, 2018; Published: December 27, 2018; doi:10.21926/obm.genet.1804057

Open Access Review

Reminiscence from Half a Century of Anti-Pneumocystis Drug Discovery and Development

Walter Hughes
Received: September 12, 2018; Published: December 5, 2018; doi:10.21926/obm.genet.1804052

Open Access Review

Pneumocystis jirovecii Pneumonia: Current Advances in Laboratory Diagnosis

Ana Luísa Tomás, Olga Matos
Received: August 21, 2018; Published: November 13, 2018; doi:10.21926/obm.genet.1804049

Open Access Review

The Relationship between Pneumocystis Infection in Animal and Human Hosts, and Climatological and Environmental Air Pollution Factors: A Systematic Review

Robert F. Miller, Laurence Huang, Peter D. Walzer
Received: September 14, 2018; Published: October 26, 2018; doi:10.21926/obm.genet.1804045