Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.
Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.
Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.
Pneumocystis: A Model of Adaptive Coevolution
Submission Deadline: October 31, 2018 (Open) Submit Now
Enrique J. Calderón
About This Topic
Pneumocystis organisms, which were first reported and named Pneumocystis carinii at the beginning of the last century, were long considered as protozoans and a single species based on morphologic features and the resistance to classical antifungal agents. The lack of a continuous in vitro system was a major obstacle to Pneumocystis research and these organisms were largely ignored until the dramatic increase in the incidence of Pneumocystis pneumonia that occurred with the emergence of the human immunodeficiency virus (HIV) pandemic, which made pneumocystosis a major medical and public health problem in the 1980s. However, this obvious pathogenic Pneumocystis–host interaction is only the tip of the iceberg, and recent findings suggest that the vast majority of mammal–Pneumocystis interactions led to relatively benign colonization, rather than pneumonia.
Molecular and biochemical studies have provided clear evidence for the placement of Pneumocystis with fungi, and based on genomic or phenotypic divergence, multiple Pneumocystis species have been recognized. Genetic data, in addition, suggested that speciation in the group resulted from long genetic isolation and co-evolution in parallel with mammal species.
In this special issue of OBM Genetics, we present the state-of-the art of the genetics and the coevolution of Pneumocystis in different mammalian species in a broad perspective, although with a particular emphasis on the human host. Reviews and methodological papers related with the topic are also welcome.
Title: Improved DNA extraction method for Pneumocystis jirovecii detection in lung tissue samples
Title: Molecular evolution of major surface glycoproteins from Pneumocystis spp: a comparative analysis
Title: Pneumocystis jirovecii pneumonia: current advances in laboratory diagnosis
Title: Dihydropteroate synthase (DHPS) polymorphisms in Pneumocystis jirovecii
Title: Pneumocystis as a co-factor in pulmonary diseases
Title: Pneumocystis species Co-evolution: state-of-the-art review
Title: The relationship between Pneumocystis infection in animal and human hosts, and climatological and environmental air pollution factors.
Title: Pneumocystis in India, an update
Title: Reminiscence and Perspectives on Half a Century with Pneumocystis
Title: How to genotype Pneumocytsis jirovecii? Impact on our understanding of interhuman transmission