TY  - JOUR
AU  - Ruaengsri, Chawannuch
AU  - Leon, Marc
AU  - Alvarez-Cortes, Miguel
AU  - Quiroz-Flores, Manuel
AU  - Shudo, Yasuhiro
PY  - 2026
DA  - 2026/01/21
TI  - Machine Perfusion in DCD Lung Transplantation: Advances in Preservation and Donor Pool Expansion
JO  - OBM Transplantation
SP  - 264
VL  - 10
IS  - 01
AB  - To address the pressing shortage of donor lungs, Donation after Circulatory Death (DCD) transplantation has become a vital strategy for expanding the donor pool. Minimizing warm ischemic injury is crucial for optimizing organ viability and function. This review synthesizes current evidence on Normothermic Regional Perfusion (NRP) and Ex-Vivo Lung Perfusion (EVLP) in DCD lung transplantation. Analysis reveals their growing efficacy in minimizing ischemic damage, facilitating organ assessment, and expanding the transplantable organ pool. Studies indicate comparable or improved recipient outcomes, including reduce primary graft dysfunction (PGD) and improved survival. However, challenges persist regarding protocol standardization, ethical considerations and long term outcome validation.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.2601264
DO  - 10.21926/obm.transplant.2601264
ID  - Ruaengsri2026
ER  -