TY  - JOUR
AU  - Vu, Van Anh
AU  - Nelson, Joelle
AU  - Sweiss, Helen
AU  - Hall, Reed
AU  - Keyt, Holly
AU  - Kincaide, Elisabeth
PY  - 2024
DA  - 2024/07/03
TI  - Impact of Intravenous Immunoglobulin Replacement Therapy on Hypogammaglobulinemia and Infection in Lung Transplant Recipients
JO  - OBM Transplantation
SP  - 220
VL  - 08
IS  - 03
AB  - Secondary hypogammaglobulinemia (HGG) from immunosuppression therapy in lung transplant recipients has been associated with increased mortality, morbidity and higher risk of infection. Intravenous immunoglobulin (IVIG) for the treatment of HGG post-lung transplant is not well studied with conflicting evidence regarding efficacy. This single-center, retrospective cohort study analyzed adult lung transplant recipients with HGG receiving ≥1 dose of IVIG 0.3-0.5 g/kg. Resolution of HGG (IgG > 600 mg/dL within 30 days of IVIG) was evaluated for optimal dose and duration of IVIG therapy. Incidence of infection, patient survival, rejection, and chronic lung allograft dysfunction-free survival at 1 year were compared between resolved and persistent HGG. Results demonstrated majority of patients 46/58 (79.3%) achieved HGG resolution. Severe HGG (IgG 
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.2403220
DO  - 10.21926/obm.transplant.2403220
ID  - Vu2024
ER  -