TY  - JOUR
AU  - Pinchera, Biagio
AU  - Carrano, Rosa
AU  - Trucillo, Emilia
AU  - D'Agostino, Alessia
AU  - Sardanelli, Alessia
AU  - Mercinelli, Simona
AU  - Salemi, Fabrizio
AU  - Piccione, Amerigo
AU  - Schettino, Elisa
AU  - Romano, Paolo
AU  - Rompianesi, Gianluca
AU  - Troisi, Roberto Ivan
AU  - Gentile, Ivan
PY  - 2023
DA  - 2023/11/01
TI  - Peri-transplant Treatment with Ceftaroline in Kidney Transplant Recipients at Risk of Donor-derived MRSA Infections: A Case Series
JO  - OBM Transplantation
SP  - 200
VL  - 07
IS  - 04
AB  - The rising prevalence of MDR pathogens has a significant impact on the recipients' outcome, as this increases the risk of graft complications and makes the management of the peri-transplant phase more difficult. Among the different MDR germs, Methicillin-resistant Staphylococcus aureus (MRSA) represents one of the most frequently isolated pathogens. We report for the first time the off-label use of Ceftaroline in six kidney transplant recipients with donor peritransplantation MRSA bacteremia at the Division of Kidney Transplant Unit of Federico II University Hospital of Naples, Italy, between September and December 2022. Each patient was followed up for the next three months after transplantation, monitoring the clinical and laboratory outcome, the risk of infection, and the efficacy and safety profile of the treatment performed. In the subsequent three months of follow-up to the transplant, none of the six patients showed donor-related infections. In particular, none of the six patients showed MRSA bacteremia or other related MRSA infections. In conclusion, our real-life experience shows that Ceftaroline could represent a valid therapeutic option in the management of solid organ transplant patients with a risk of donor-derived MRSA infection. However, despite the few cases considered, this approach deserves further investigation in ad hoc studies or clinical trials due to our positive results.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.2304200
DO  - 10.21926/obm.transplant.2304200
ID  - Pinchera2023
ER  -