TY  - JOUR
AU  - Santos, Alfonso
AU  - Belal, Amer
AU  - Ibrahim, Hisham
AU  - Leghrouz, Muhannad
PY  - 2023
DA  - 2023/02/21
TI  - Non-Renal Factors Associated with Simultaneous Liver-Kidney Transplant in Patients with End-Stage Liver Disease and Stage 3-5 Chronic Kidney Disease Not Requiring Dialysis
JO  - OBM Transplantation
SP  - 175
VL  - 07
IS  - 01
AB  - We aimed to identify the non-renal risk factors for simultaneous liver-kidney transplantation (SLKT) vs. liver transplantation alone (LTA) in end-stage liver disease (ESLD) patients with estimated glomerular filtration rate (eGFR) 60 years (OR = 0.25, CI = 0.19-0.32), female recipient sex (OR = 0.48, CI = 0.43-0.54), hepatocellular carcinoma (OR = 0.53, CI = 0.35-0.81), and transplant center procedure volume tercile ranks 3rd (OR = 0.74, CI = 0.62-0.89) and 2nd (OR = 0.78, CI = 0.64-0.95). Model for end-stage liver disease scores have varying associations with SLKT vs. LTA, depending on calculation time: at wait listing or transplant. CKD-5 and -4 at wait listing (WL) and transplant were the risk factors with highest point estimates for SLKT vs. LTA. In patients with ESLD and CKD stage 3-5, not on dialysis, strong non-renal risk factors favoring SLKT versus LTA include: prolonged waitlist time, African American or Hispanic race/ethnicity, previous liver transplant, and diabetes. Some novel associations found between risk factors and likelihood of SLKT need further study for confirmation. Lack of uniform criteria for SLK allocation during the period studied is a major limitation of the study.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.2301175
DO  - 10.21926/obm.transplant.2301175
ID  - Santos2023
ER  -