TY  - JOUR
AU  - Adamo, Ginevra Giovanna
AU  - D'Angelo, Sergio
AU  - Yu, Angeli Christy
AU  - Pellegrini, Marco
AU  - Bernabei, Federico
AU  - Scorcia, Vincenzo
AU  - Giannaccare, Giuseppe
PY  - 2022
DA  - 2022/08/02
TI  - Bilateral Corneal Perforation in a Patient with Chronic Ocular Graft-Versus-Host Disease: A Case Report and Literature Review
JO  - OBM Transplantation
SP  - 164
VL  - 06
IS  - 03
AB  - Graft-versus-host disease (GVHD) is a serious complication that may occur in patients receiving allogeneic hematopoietic stem cell transplant (HSCT). GVHD occurs because of the immunological reaction between the donor’s T cells and the recipient’s antigens; GVHD may develop in different tissues, including the eye. Corneal perforation is an uncommon but vision-threatening manifestation of GVHD. We reported the case of a 65-year-old male patient who developed corneal perforation sequentially in both eyes 3 years after receiving HSCT. Conservative treatment with topical steroids and lubricants, bandage contact lens, and lacrimal punctal occlusion surgery resulted in the successful resolution of the corneal perforation with satisfactory visual recovery in the right eye. Therefore, corneal perforation can occur as the presenting manifestation of ocular GVHD. Regular ophthalmological examinations are recommended after HSCT to enable the early diagnosis of ocular GVHD and prompt treatment initiation.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.2203164
DO  - 10.21926/obm.transplant.2203164
ID  - Adamo2022
ER  -