TY  - JOUR
AU  - El-Serafi, Ibrahim
AU  - Oerther, Sandra
AU  - Zhao, Ying
AU  - Hassan, Moustapha
PY  - 2022
DA  - 2022/07/27
TI  - The Role of Cytochrome P450 2J2 in Cancer: Cell Protector, Therapeutic Target, or Prognostic Marker?
JO  - OBM Transplantation
SP  - 163
VL  - 06
IS  - 03
AB  - Cytochrome P450 2J2 (CYP2J2) is one of the recently discovered enzymes that is involved in the metabolism of several drugs. It is mainly an extrahepatic enzyme which can, to some extent, explain some the drugs’ side effects such as cyclophosphamide (Cy). Cyclophosphamide is an alkylating agent that is commonly used in conditioning prior to stem cell transplantation. It is a prodrug that is bio-activated by several CYPs including CYP2J2. Cy is known to have several side effects and its extrahepatic activation by CYP2J2 may explain the mechanism of some of these side effects. On the other hand, CYP2J2 is overexpressed in several types of cancer and its inhibition (e.g. by Cy) reduces the cancer cells survival. Taken together, CYP2J2 is considered as a potential therapeutic target and prognostic marker for cancer patients in addition to its role in drugs extrahepatic metabolism.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.2203163
DO  - 10.21926/obm.transplant.2203163
ID  - El-Serafi2022
ER  -