TY  - JOUR
AU  - Hagen, Patrick
AU  - Singh, Shruti
AU  - Qin, Shuai
AU  - Campo, Loredana
AU  - Adams, William
AU  - Tsai, Stephanie
AU  - Hossain, Nasheed
AU  - Smith, Scott
AU  - Stiff, Patrick
PY  - 2021
DA  - 2021/02/07
TI  - Umbilical Cord Blood as an Alternate Donor Sources for High Risk Elderly Patients Undergoing Allogeneic Stem Cell Transplantation for Hematological Malignancies
JO  - OBM Transplantation
SP  - 136
VL  - 05
IS  - 01
AB  - Allogeneic stem cell transplantation remains the only curative option for many hematological malignancies. Umbilical cord blood (UCB) is an alternate donor source with potentially increased morbidity in elderly patients. We evaluated outcomes in alternate donor sources, prior to the initiation of haploidentical transplantation at our institution, of matched unrelated donor (MUD) and UCB in elderly patients (mean age 64, range 60-75). One hundred and eighty-four patients were included (MRD: 57; MUD: 69; UCB: 58). There was no difference in acute or chronic graft versus host disease among donor sources (all p > .05). In this high-risk population, 128 (70%) had either a high disease risk index or high (>2) comorbidity index. Median progression free survival (PFS) was lowest among UCB (5.5 months; 95% CI 2.8-9.4) and MUD (5.6 months; 95% CI 3.7-17.7) as compared to MRD (18.3 months; 95% CI 8.4-64.8). On multivariable analysis, the rate of mortality was higher for UCB than MRD patients (1.88, 95% CI 1.04 – 3.37), but there was no difference between UCB and MUD (p = .61) or between MUD and MRD (p = .25). Conclusions were similar for PFS. Our experience shows that even in this high-risk elderly cohort, UCB continues to be a viable alternate donor source.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.2101136
DO  - 10.21926/obm.transplant.2101136
ID  - Hagen2021
ER  -