TY  - JOUR
AU  - Bejanyan, Nelli
AU  - Lazaryan, Aleksandr
AU  - Oliver, Graf
AU  - Eckfeldt, Craig E.
AU  - Deshmankar, Bhagyashree
PY  - 2020
DA  - 2020/09/18
TI  - Severe Hypercholesterolemia Associated with Steroid-Refractory Acute Liver GVHD: Unusual Complication of Allogeneic Hematopoietic Cell Transplantation
JO  - OBM Transplantation
SP  - 118
VL  - 04
IS  - 03
AB  - Severe hypercholesterolemia is an uncommon complication of allogenic hematopoietic cell transplantation (HCT). Treatment options for hypercholesterolemia due to liver graft-versus-host disease (GVHD) are limited because many antilipidemic medications are known to worsen hepatic functions. We report our experience on a case of a 38-year-old male with Philadelphia chromosome positive acute lymphoblastic leukemia presenting with steroid-refractory hepatic and lower gastrointestinal acute GVHD after matched sibling donor peripheral blood myeloablative HCT who developed severe hypercholesterolemia (>1,000mg/dl). The patient was effectively treated with extracorporeal photopheresis for GVHD and severe hypercholesterolemia resolved after weeks of therapy with lipoprotein apheresis.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.2003118
DO  - 10.21926/obm.transplant.2003118
ID  - Bejanyan2020
ER  -