TY  - JOUR
AU  - Ng, Natasha
AU  - Tan, Wei Xuan
AU  - Koh, Yexin
AU  - Teo, Adrian
PY  - 2019
DA  - 2019/06/21
TI  - Human Islet Isolation and Distribution Efforts for Clinical and Basic Research
JO  - OBM Transplantation
SP  - 068
VL  - 03
IS  - 02
AB  - The ability to obtain purified human islets routinely and reproducibly has enabled substantial progress in providing a safe and reliable treatment option for adult Type 1 diabetes patients. The availability of human islets for basic research has also significantly impacted the progress of understanding human islet biology and consequently, diabetes pathophysiology. There are now approximately 70 human islet isolation centers documented around the world, as well as multiple coordinated human islet distribution programs to facilitate the exchange of knowledge and sharing of this precious resource. This review will provide a brief overview of the steps involved in human islet isolation and dissemination, and discuss key considerations in light of the major challenges faced during this process. Another important goal of the review is to summarize current human islet distribution efforts nationally, regionally and internationally. The review will then highlight the value of human islets for both clinical transplantation and basic research, in particular underlining selected research studies that have significantly advanced our understanding of human islet biology.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1902068
DO  - 10.21926/obm.transplant.1902068
ID  - Ng2019
ER  -