TY  - JOUR
AU  - Sakata, Naoaki
AU  - Yoshimatsu, Gumpei
AU  - Kodama, Shohta
PY  - 2019
DA  - 2019/04/03
TI  - Islet Autotransplantations for Total Pancreatectomy
JO  - OBM Transplantation
SP  - 059
VL  - 03
IS  - 02
AB  - Total pancreatectomy (TP) is performed for not only malignant pancreatic diseases but also benign disease such as chronic pancreatitis or pancreatic injury. However, because this surgery involves removal of the whole pancreas, both exocrine and endocrine pancreatic functions are abolished, significantly impairing the nutritional statuses of patients as well as having other detrimental outcomes. Thus, especially in benign cases additional treatment to recover endocrine function is recommended, as permanent endocrine dysfunction significantly decreases quality of life. Historically, islet and pancreas allotransplantations have been performed to recover endocrine function in severely diabetic patients. In TP patients, islet autotransplantation (IATx) can be performed in patients with benign pancreatic disease with absent endocrine function after removal of the pancreas. Autotransplantation rescues pancreatic function and prevents the onset of secondary diabetes mellitus. In this review article, we describe the current status of TP with IATx and include one of our own cases.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1902059
DO  - 10.21926/obm.transplant.1902059
ID  - Sakata2019
ER  -