TY  - JOUR
AU  - Beamish, Christine
AU  - sabek, Omaima
PY  - 2019
DA  - 2019/03/05
TI  - Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Function
JO  - OBM Transplantation
SP  - 055
VL  - 03
IS  - 01
AB  - Islet transplantation is a promising technique for millions of patients with diabetes, but is severely limited by a shortage of cadaveric donor islets, and more so because of stringent inclusion criteria for organ donation including donor metabolic function, age, and comorbidities. The impact of these diverse factors on islet health have led to a broad investigation of global influences on islet biology, not least of all, characterization of mature, functional cellular identity and maintenance of appropriate endocrine lineage. This review will discuss variables involved in donor islet inclusion characteristics and metabolic function, and related impact on islet transplant success; inherent and imposed models of islet and β-cell heterogeneity and plasticity; and the role of cellular dedifferentiation of islets and β-cells in the normal and pathophysiological states, including aging, diabetes subtypes, and islet transplantation. Examination of potential strategies for reduction of metabolic stress by endogenous and exogenous modes is further discussed.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1901055
DO  - 10.21926/obm.transplant.1901055
ID  - Beamish2019
ER  -