TY  - JOUR
AU  - Darden, Carly
AU  - Vasu, Srividya
AU  - Naziruddin, Bashoo
AU  - Lawrence, Michael
PY  - 2019
DA  - 2019/01/29
TI  - Targeting Acute Islet Inflammation to Preserve Graft Mass and Long-Term Function
JO  - OBM Transplantation
SP  - 043
VL  - 03
IS  - 01
AB  - Islet transplantation is a minimally invasive cell based replacement therapy to prevent or reverse diabetes or hypoglycemia through natural hormonal responses to regulate blood glucose. However, extending the islet graft functional lifespan remains a challenge that prevents long-term success and widespread use of the procedure. Islets are subject to stress and damage and undergo immunological assault during transplantation procedures. Current treatments to prevent immune reactivity toward the graft come with toxic side effects, and damage to islets and loss of graft function still occurs. Accumulating evidence suggests that acute inflammatory reactions contribute to a significant loss of islet cell mass early in the transplant process. Inflammatory reactions involving a blood coagulation cascade and communication between islet cells and immune cells can destroy more than half the islet mass. These cyclic events link innate and adaptive immune responses that lead to graft failure. In this review, we discuss key components and strategies to target islet cell inflammation and delink the progression of inflammatory islet-immune cell responses that contribute to islet graft destruction.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1901043
DO  - 10.21926/obm.transplant.1901043
ID  - Darden2019
ER  -