TY  - JOUR
AU  - Pitrak, David
AU  - Pursell, Kenneth
AU  - Newman, Margaret
PY  - 2019
DA  - 2019/01/20
TI  - Parvovirus B19 Infection in Solid Organ Transplantation: Report of A Case and A Review
JO  - OBM Transplantation
SP  - 040
VL  - 03
IS  - 01
AB  - Infection with parvovirus B19 is common, with up to 55% of adults showing seropositive evidence of prior infection.  Clinical disease can occur due to acute infection, secondary infection, or reactivation.  The clinical presentation of primary infection depends on age, the presence of a hematologic condition, and immune status.  It is an uncommon infection in solid organ transplant (SOT) recipients that has atypical features, usually presenting with pure red cell aplasia which is refractory to erythropoietin (EPO) and which can be transfusion dependent.  Plasma polymerase chain reaction (PCR) measurement of DNA, both qualitative and quantitative, can be very helpful for diagnosis, but a negative test does not exclude infection.  In those cases, bone marrow biopsy may be needed to document the viral infection.  Loss of or inability to produce neutralizing antibodies is the immune deficit leading to chronic parvovirus disease, in which serologic diagnosis is unreliable.  An even more unusual manifestation of parvovirus infection is end organ disease, though more common in immunocompromised individuals.  Intravenous immunoglobulin (IVIG) replacement therapy appears to be most effective treatment, although there may also be a role for reduction in immune suppression.  The ability to prevent this unusual infection is limited, as patients who are asymptomatic may transmit the disease.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1901040
DO  - 10.21926/obm.transplant.1901040
ID  - Pitrak2019
ER  -