TY  - JOUR
AU  - Robinson, Makeda
AU  - Enriquez, Kyle
AU  - Ho, Dora Y.
PY  - 2019
DA  - 2019/01/08
TI  - A Tale of Two Flaviviruses: West Nile Virus and Zika Virus in Solid Organ Transplantation
JO  - OBM Transplantation
SP  - 038
VL  - 03
IS  - 01
AB  - Flaviviruses can cause epidemics and endemics with substantial public health threat and economic impacts. In the last few decades, many flaviviruses have re-emerged or expanded their territories to new regions or continents, including West Nile virus that has become endemic in the US since its arrival in 1999 and Zika virus that recently spread across the Americas.  These events demonstrate the speed with which a vector-born pathogen can disseminate when introduced into a susceptible population with competent vectors. The threat of flaviviruses has special relevance to the solid organ transplant populations because of the possibility of donor-derived transmission and increased disease severity in immunocompromised patients. This review will focus on the clinical manifestations, diagnosis, treatment and prevention of flavivirus infection, with emphasis on WNV and ZIKV as they both garnered much attention of the SOT arena when introduced into the US and they epitomize the unpredictability of the epidemiological and clinical features of flaviviruses.  Several other flaviviruses will also be discussed when data regarding transplant patients are available.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1901038
DO  - 10.21926/obm.transplant.1901038
ID  - Robinson2019
ER  -