TY  - JOUR
AU  - Quintana, Jeremy M.
AU  - Stinchcomb, Alexandra L.
AU  - Kostyo, Jessica H.
AU  - Robichaud, Blair M.
AU  - Plunk, Michael A.
AU  - Kane, Robert R.
PY  - 2018
DA  - 2018/12/28
TI  - Chemical Strategies for Improving Islet Transplant Outcomes
JO  - OBM Transplantation
SP  - 036
VL  - 02
IS  - 04
AB  - Islet transplantation has proven to be a viable treatment for individuals suffering from both Type 1 Diabetes Mellitus (T1D) and chronic pancreatitis. However, a variety of challenges limit the effectiveness of this procedure by reducing the number of islets that survive the harvesting and transplantation processes. Increasing islet survival would increase the long-term effectiveness of the procedure and allow this technique to be used in more patients.  A number of factors have been shown to improve the outcomes of pancreatic islet transplantation, including the inhibition of apoptosis and inflammation, the prevention of coagulation, and the inhibition of the adaptive immune response. In this review, we will discuss various chemical strategies reported in the literature for the preservation of islet graft function after transplantation, including the adoption of anti-inflammatory and immune suppressing molecules, islet encapsulation, and islet surface modification.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1804036
DO  - 10.21926/obm.transplant.1804036
ID  - Quintana2018
ER  -