TY  - JOUR
AU  - Oh, Byoung Chol
AU  - Grzelak, Michael
AU  - Guo, Yi-nan
PY  - 2018
DA  - 2018/12/13
TI  - Cell based Therapy in Transplantation
JO  - OBM Transplantation
SP  - 031
VL  - 02
IS  - 04
AB  - One of the major hurdles still facing the field of transplantation is the management of immunosuppression and the morbidity that results from treatment. Due to toxicity and complications from a maintenance immunosuppression therapies, a necessary improvement in post-transplant immunosuppressive therapies must be the development of a low-side effect therapy. Cell-based therapies as an emerging candidate offer a novel approach to generating graft tolerance, and when utilized within a combination therapeutic strategy, they may allow for targeted allograft protection with higher safety. In this review, the results and advances of these cell-based approaches including regulatory T cells, IL-10 producing Tr1 cells, tolerogenic dendritic cells and mesenchymal stem cells in animal studies and clinical trials will be discussed and compared.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1804031
DO  - 10.21926/obm.transplant.1804031
ID  - Oh2018
ER  -