TY  - JOUR
AU  - Huppert, Laura A.
AU  - Sinclair, Marie
AU  - Lai, Jennifer C.
PY  - 2018
DA  - 2018/11/28
TI  - Identifying Novel Biomarkers of Frailty in Cirrhosis: Results from an Unbiased Proteomics Search from the Functional Assessment in Liver Transplantation (FrAILT) Study
JO  - OBM Transplantation
SP  - 028
VL  - 02
IS  - 04
AB  - BACKGROUND: Patients with cirrhosis suffer not only from commonly-diagnosed portal hypertensive complications such as ascites and hepatic encephalopathy but also from more insidious effects of chronic liver failure including muscle wasting, under-nutrition, and functional decline. These manifestations of physical frailty have been demonstrated to predict mortality in patients with cirrhosis independently of liver disease severity, but objective biomarkers associated with physical frailty in cirrhosis are needed. The aim of this work is to identify biomarkers associated with physical frailty among patients with cirrhosis.
METHODS: Mass spectrometry was used to identify serum proteins that were differentially expressed between frail and non-frail patients with cirrhosis (15 frail and 15 non-frail, matched for age, gender, and MELDNa). Then, eleven proteins were selected for further analysis based on those with the lowest p-value and largest differential. ELISA assays were used to validate and quantify differences in protein concentration (37 frail and 37 non-frail patients with cirrhosis, matched for age, gender, and MELDNa).
RESULTS: Mass spectrometry identified twenty-five proteins that were differentially expressed in frail versus non-frail patients with cirrhosis (p
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1804028
DO  - 10.21926/obm.transplant.1804028
ID  - Huppert2018
ER  -