TY  - JOUR
AU  - Chatenoud, Lucienne
AU  - YOU, Sylvaine
PY  - 2018
DA  - 2018/11/09
TI  - The Concerted Action of Multiple Mechanisms to Induce and Sustain Transplant Tolerance
JO  - OBM Transplantation
SP  - 025
VL  - 02
IS  - 04
AB  - Transplant tolerance has been achieved in experimental models using immune intervention strategies. Yet, their clinical translation remains unsuccessful and requires further optimization of immunotherapeutic regimens based on a deeper understanding of the cellular and molecular mechanisms at play in the induction and maintenance phases of immune tolerance. Intensive investigations have shed the light on the tolerogenic networks underlying graft survival and have unraveled their complexity, which may depend on several parameters such as intrinsic features of the transplant itself (organs/tissues/cells), the type of immunotherapy and the therapeutic window used. Although it is now fairly well-established that Foxp3+ regulatory T lymphocytes (Tregs) play a central role in these networks, a wealth of evidence points to multiples mechanisms, including alloreactive T cell depletion and T cell anergy that, in addition to Treg-mediated suppression, are all engaged and cooperate in a timely manner to tip the balance from rejection towards robust and sustained tolerance. All this supports the fact that the clinical development of tolerance-inducing therapies may reside in the triggering of these multiple pathways to achieve long-term graft survival in transplanted patients while minimizing/withdrawing immunosuppression.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1804025
DO  - 10.21926/obm.transplant.1804025
ID  - Chatenoud2018
ER  -