TY  - JOUR
AU  - Rowan, Courtney M
AU  - Tillman, Emma M
AU  - Teagarden, Alicia M
PY  - 2018
DA  - 2018/10/29
TI  - Early Nutrition during Critical Illness in Pediatric Patients Post-Hematopoietic Cell Transplantation
JO  - OBM Transplantation
SP  - 022
VL  - 02
IS  - 04
AB  - Background: Hematopoietic cell transplant (HCT) patients are a high-risk population for poor nutrition and decreased survival. There is little data on how nutrition in pediatric HCT patients affects need for critical care interventions and outcomes. Methods: We hypothesized that patients who did not meet goal nutrition by 72 hours post-admission to the pediatric intensive care unit (PICU) had increased in-hospital mortality and increased need for critical care interventions. We performed a retrospective cohort study of pediatric HCT patients that were admitted to the PICU during their transplant admission. Patients were included if they were <21 years and post-allogeneic HCT. Goal nutrition was defined as the goal kcal/day or kcal/kg/day set by the dietician using the Schofield equation with appropriate age, gender, stress and activity factors. We compared patients who did not meet goal nutrition within 72 hours of PICU admission to those who met goal nutrition within 72 hours. Results: Twenty-eight patients were included in the study and 54% (n=15) did not meet goal nutrition by 72 hours from PICU admission. Those that did not meet goal nutrition by 72 hours had higher rates of in-hospital mortality (67% vs 23%; p=0.02), increased 12-month post-HCT mortality (80% vs 31%; p <0.01) and increased rates of veno-occlusive disease (67% vs 15%; p <0.01). Conclusions: We conclude that there is an association with poor nutrition in critically ill pediatric HCT patients and decreased survival. Further research is needed to evaluate the effect of improved nutrition at admission to the PICU and outcomes.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1804022
DO  - 10.21926/obm.transplant.1804022
ID  - Rowan2018
ER  -