TY  - JOUR
AU  - Ali, Khawla F.
AU  - Martin, Vicente T. San
AU  - Stevens, Tyler
AU  - Walsh, Matthew
AU  - Bottino, Rita
AU  - Trucco, Massimo
AU  - Hatipoglu, Betul
PY  - 2018
DA  - 2018/07/02
TI  - Autoimmunity in Autologous Islet Transplantation
JO  - OBM Transplantation
SP  - 014
VL  - 02
IS  - 03
AB  - Total pancreatectomy (TP) is increasingly being utilized for definitive treatment in patients with debilitating chronic pancreatitis (CP). In an effort to prevent surgical diabetes, the procedure can be performed in conjunction with transplantation of islets of Langerhans recovered from the patients’ own resected pancreas (autologous islet transplantation, AIT). Given that patients undergoing TP and AIT are traditionally assumed not to be at risk for the development of beta-cell autoimmunity, it is possible that the presence of autoimmune islet graft failure has been overlooked and underreported in this patient population. Herein, we describe two cases who underwent TP and AIT and later developed new-onset beta-cell autoimmunity (as evidenced by de novo glutamic acid decarboxylase antibody positivity), accompanied by complete insulin-dependent states. These cases emphasize the need for considering a possible autoimmune phenomenon in the workup of TP and AIT patients who manifest with unexpected and rapid deterioration in their glycemic control.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1803014
DO  - 10.21926/obm.transplant.1803014
ID  - Ali2018
ER  -