TY  - JOUR
AU  - Shindo, Yoshitaro
AU  - Kanak, Mazhar
PY  - 2018
DA  - 2018/06/22
TI  - Regulation of Inflammatory Response in Islet Transplantation
JO  - OBM Transplantation
SP  - 013
VL  - 02
IS  - 02
AB  - Islet cell transplantation is a developing treatment for patients suffering from severe Type-1 diabetes. The long-term insulin independence after islet cell transplantation has been difficult to achieve, and this has been linked to several factors. One of the major cause of poor long-term outcome is inflammation surrounding the islets. Inflammation in islets is caused art several stages, donor induced, during organ preservation, islet isolation stress, peri-transplant inflammation or instant blood mediated inflammatory reaction (IBMIR), and post-transplant hypoxia. In addition to inflammation, auto/allo-immune attack causes rejection and the toxicity of the immunosuppressive agents used can also affect islet transplant outcomes. In this review, we will summarize the various inflammatory processes that occur during islet transplantation along with past and previous approaches used to reduce inflammation in pre-clinical and clinical studies.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1802013
DO  - 10.21926/obm.transplant.1802013
ID  - Shindo2018
ER  -