TY  - JOUR
AU  - BRAYMAN, KENNETH
AU  - CHHABRA, PREETI
PY  - 2018
DA  - 2018/06/05
TI  - Stem Cell Strategies to Promote Islet Transplantation Outcomes
JO  - OBM Transplantation
SP  - 010
VL  - 02
IS  - 02
AB  - Pancreas or islet transplantation is the only reliable cure for Type 1 Diabetes. However, shortage of donor tissue supply, longitudinal graft attrition due to innate and adaptive immunity and the recurrence of autoimmunity, as well as the harmful side-effects of chronic immunosuppressive therapy limit the wide-spread acceptance of islet transplantation as a mainstream cure for autoimmune diabetes. Herein, preclinical and clinical stem-cells based research approaches aimed at obtaining large quantities of islets for transplantation, overcoming islet graft loss and dysfunction post-transplantation, discovering alternate transplant sites to improve graft survival, and understanding the concepts of immunogenicity and autoimmunity to auto-antigens expressed by autologous stem cells-derived β−cells are discussed in depth.
SN  - 2577-5820
UR  - https://doi.org/10.21926/obm.transplant.1802010
DO  - 10.21926/obm.transplant.1802010
ID  - BRAYMAN2018
ER  -