TY  - JOUR
AU  - Khalil, Ahmad M.
PY  - 2026
DA  - 2026/05/29
TI  - Applications of CRISPR-Cas9 Gene Editing Technology in Food Allergy Therapy: A Comprehensive Review
JO  - Recent Progress in Science and Engineering
SP  - 009
VL  - 02
IS  - 02
AB  - Worldwide, the incidence of allergenicity is rising rapidly, making it an ongoing clinical challenge and public health concern. The current treatment options for allergies include allergen avoidance, medications to improve symptoms, and immunotherapy to desensitize affected individuals to specific allergens. However, these approaches have limitations, and there is an urgent need for novel and more effective therapies. Allergies are a compelling candidate for gene editing (GE) given their prevalence and the inadequacies of existing treatments. Repurposing present allergy medications and emerging novel therapies may be possible with the aid of genomics-guided determination of prospective therapeutic targets for the illness. The emergence of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-GE technology, which uses RNA to guide DNA targeting, has allowed the generation of customized organisms for specific traits. The novel genome-editing tools have shown promising potential to transform allergy research and treatment, offering new hope for patients with severe allergies. By allowing accurate alterations of the genome, GE can be used to delete, correct specific allergen gene (s) that make a person susceptible to allergies, or interfere with the transcription of those genes. Gene editing may be used to engineer immune cells to become more tolerant of particular allergens. This review goes beyond traditional disease therapies by highlighting the latest breakthroughs in this revolutionary field. The applications exemplified in this review reveal how CRISPR can be used to identify the function of allergen proteins and engineer allergen-free plants to develop hypoallergenic foods. But some allergens play vital roles in physiological processes, such as ameliorating biotic and abiotic stress in plants and disease in animals. Just targeting their genes with CRISPR to abolish expression is not always feasible. The benefits and limitations of CRISPR-Cas9-based GE technology are compared with current treatment options.
SN  - 3067-4573
UR  - https://doi.org/10.21926/rpse.2602009
DO  - 10.21926/rpse.2602009
ID  - Khalil2026
ER  -