TY  - JOUR
AU  - Sathvara, Jignesh P.
AU  - Jadeja, Rajendrasinh N.
PY  - 2026
DA  - 2026/04/30
TI  - Novel Bis-Quadridentate Pyrazolone-Based Ligands and Zinc(II) Complexes: Spectroscopic Characterization and <i>In Vitro</i> Anti-Malarial Activity
JO  - Recent Progress in Science and Engineering
SP  - 007
VL  - 02
IS  - 02
AB  - A new series of bis-quadridentate ligands (L1-L3) and their corresponding zinc(II) complexes (Complex 1-3) were rationally designed, synthesized, and characterized. The ligand framework features multiple donor sites that enable stable coordination to zinc(II), yielding well-defined metal complexes. The structures of the synthesized compounds were confirmed using a combination of analytical and spectroscopic techniques. Thermal gravimetric analysis revealed that all zinc complexes exhibit exceptional thermal stability, remaining stable up to 500°C, indicative of robust metal–ligand interactions. The in vitro anti-plasmodial activity of the ligands and their zinc complexes was evaluated against Plasmodium falciparum using a JSB staining-assisted microscopic method. The zinc complexes demonstrated enhanced activity relative to the free ligands, with half-maximal inhibitory concentration (IC50) values of 0.67 µg mL-1 (1), 0.53 µg mL-1 (2), and 0.59 µg mL-1 (3). In contrast, the free ligands exhibited IC50 values ranging from 0.69 to 0.84 µg mL-1.
SN  - 3067-4573
UR  - https://doi.org/10.21926/rpse.2602007
DO  - 10.21926/rpse.2602007
ID  - Sathvara2026
ER  -