TY  - JOUR
AU  - Lamberti, Angelina
AU  - Haddad, Sinan
AU  - Wagenpfeil, Stefan
AU  - Vogt, Thomas
AU  - Reichrath, Jörg
PY  - 2025
DA  - 2025/10/29
TI  - Clinical Trials Characterizing the Serum 25-Hydroxyvitamin D Response to Vitamin D Supplementation in Children: A Systematic Review and Meta-Analysis
JO  - Recent Progress in Nutrition
SP  - 024
VL  - 05
IS  - 04
AB  - Recommendations for vitamin D supplementation are essential for the prevention and therapy of vitamin D deficiency. However, reliable data remain lacking for children, as most intake recommendations are based on individual studies. This work aimed to obtain reliable data that allow health authorities to re-evaluate recommendations for oral vitamin D uptake in children. We conducted a systematic literature search in MEDLINE/PubMed on vitamin D supplementation in children. All randomized controlled trials (RCTs) published up to June 6th, 2016, and that met special inclusion criteria were included. Egger's test was performed to rule out publication bias, and a quality assessment of the RCTs was performed using the Jadad score. The quality of evidence was assessed using the GRADE method. The meta-analysis was performed according to the PRISMA-P recommendations. A total of seventeen RCTs met the inclusion criteria. On average, the baseline 25-hydroxyvitamin D concentration was 42.48 +/- 17.82 nmol/L in the intervention groups and 41.42 +/- 16.74 nmol/L in the control groups (mean value +/- standard deviation). At the beginning of the study periods, mean serum 25-hydroxyvitamin D values were deficient in 41% of the RCTs in the deficient range, and in 30% in the insufficient range, respectively. After vitamin D supplementation, the intervention groups showed a significant increase in serum 25-hydroxyvitamin D concentration compared with the control groups. (evidence level high ++++). The 25-hydroxyvitamin D level increased by an average of 25.57 nmol/L (CI: 19.59, 31.56 nmol/L, p < 0.001). The effect was already significant after a few weeks (studies shorter than 16 weeks - increase of 26.23 nmol/L), and vitamin D administration over a more extended period did not result in a greater increase in 25-hydroxyvitamin D concentrations (25.45 nmol/l rise after 52 weeks). After supplementation, there was no vitamin D deficiency in any of the intervention groups, but in 18% of the studies, the 25-hydroxyvitamin D level was still in the insufficient range (
SN  - 2771-9871
UR  - https://doi.org/10.21926/rpn.2504024
DO  - 10.21926/rpn.2504024
ID  - Lamberti2025
ER  -