TY  - JOUR
AU  - Neacsu, Madalina
AU  - Anderson, Susan
AU  - Verschoor, Pola
AU  - Vaughan, Nicholas
AU  - Horgan, Graham
AU  - Hulshof, Toine
AU  - Duncan, Sylvia
AU  - Duthie, Susan
AU  - Russell, Wendy
PY  - 2021
DA  - 2021/12/17
TI  - Consumption of a Recommended Serving of Wheat Bran Cereals Significantly Increases Human Faecal Butyrate Levels in Healthy Volunteers and Reduces Markers of Inflammation <i>Ex Vivo</i>
JO  - Recent Progress in Nutrition
SP  - 002
VL  - 01
IS  - 04
AB  - Wheat bran cereals are an important source of dietary fibre. The aim of the study was to investigate if a high intake (120 g) of fibre rich breakfast cereal (which delivers the UK Government guidelines for fibre intake in one serving but is three-fold higher than the manufacturers recommended serving) has additional potential health benefits compared to the recommended serving (40 g, containing 11 g of dietary fibre). To assess this, the study determined the short chain fatty acid (SCFA) profiles in human faecal, urine and plasma samples after consumption of two different servings of fibre-rich cereal. Inhibition of prostanoid production was measured (ex vivo) in human colonic fibroblast cells after cytokine (IL-1β) inflammation stimulation. Eight healthy volunteers, 18-55 years old; BMI (18-30 kg/m2) consumed the wheat bran-rich “ready to eat cereal”, at both the high (120 g) serving and recommended (40 g) serving. Faecal, urine and plasma samples were collected at baseline, throughout the five-hour intervention period and approximately 24 hours following consumption. Faecal butyrate showed the largest increase (p
SN  - 2771-9871
UR  - https://doi.org/10.21926/rpn.2104002
DO  - 10.21926/rpn.2104002
ID  - Neacsu2021
ER  -