TY - JOUR AU - Neacsu, Madalina AU - Anderson, Susan E. AU - Verschoor, Pola AU - Vaughan, Nicholas J. AU - Horgan, Graham W. AU - Hulshof, Toine AU - Duncan, Sylvia H. AU - Duthie, Susan AU - Russell, Wendy R. PY - 2021 DA - 2021/12/17 TI - Consumption of a Recommended Serving of Wheat Bran Cereals Significantly Increases Human Faecal Butyrate Levels in Healthy Volunteers and Reduces Markers of Inflammation <i>Ex Vivo</i> JO - Recent Progress in Nutrition SP - 002 VL - 01 IS - 04 AB - Wheat bran cereals are an important source of dietary fibre. The aim of the study was to investigate if a high intake (120 g) of fibre rich breakfast cereal (which delivers the UK Government guidelines for fibre intake in one serving but is three-fold higher than the manufacturers recommended serving) has additional potential health benefits compared to the recommended serving (40 g, containing 11 g of dietary fibre). To assess this, the study determined the short chain fatty acid (SCFA) profiles in human faecal, urine and plasma samples after consumption of two different servings of fibre-rich cereal. Inhibition of prostanoid production was measured (ex vivo) in human colonic fibroblast cells after cytokine (IL-1β) inflammation stimulation. Eight healthy volunteers, 18-55 years old; BMI (18-30 kg/m2) consumed the wheat bran-rich “ready to eat cereal”, at both the high (120 g) serving and recommended (40 g) serving. Faecal, urine and plasma samples were collected at baseline, throughout the five-hour intervention period and approximately 24 hours following consumption. Faecal butyrate showed the largest increase (p SN - 2771-9871 UR - https://doi.org/10.21926/rpn.2104002 DO - 10.21926/rpn.2104002 ID - Neacsu2021 ER -