TY - JOUR AU - Silver, Frederick H. AU - Kelkar, Nikita AU - Deshmukh, Tanmay AU - Horvath, Istvan AU - Shah, Ruchit G. PY - 2020 DA - 2020/04/29 TI - Mechano-Vibrational Spectroscopy of Tissues and Materials Using Vibrational Optical Coherence Tomography: A New Non-Invasive and Non-Destructive Technique JO - Recent Progress in Materials SP - 010 VL - 02 IS - 02 AB - Elastic moduli of tissues and synthetic polymeric materials are important design properties needed to develop new implants. In this paper we report the use of vibrational optical coherence tomography (VOCT) to measure the resonant frequency and calculate the modulus of tissues and synthetic polymers non-invasively and non-destructively in vitro and in vivo. Values of tissue and polymer moduli were obtained by applying an audible sinusoidal sound wave to the surface of each specimen. The sound wave travels to the interior of the material and is reflected back to the surface from underlying layers. A spectrum of resonant frequencies and moduli are then obtained. By analyzing the frequencies at which the maximum displacements are observed the resonant frequencies are determined of the material components and the moduli can then be calculated from calibration equations. The characteristic spectrum of resonant frequencies measured is a finger print by which the composition of the underlying tissue components can be determined using VOCT. The resonant frequencies of cells and tissues range from about 40 Hz for fat to about 990 Hz for lamellar bone. The modulus for these tissues ranges from about 1 MPa (cells) to that for extracellular matrix components that range from 2 to 173 MPa (tissue macromolecular components). Measurements reported on synthetic polymers indicate that the resonant frequency ranges from 80 Hz (silicone rubber) to 2800 Hz (acrylonitrile butadiene styrene) and values of the modulus are found to be between 2 MPa and 2120 MPa, respectively. The resonant frequency and modulus are shown to decrease as a result of fatigue in Viton rubber. It is concluded that the width of the resonant frequency peak is related to the molecular weight distribution and that VOCT may serve as method to rapidly determine molecular weight distributions and properties after cyclic loading of uncrosslinked and crosslinked polymers. SN - 2689-5846 UR - https://doi.org/10.21926/rpm.2002010 DO - 10.21926/rpm.2002010 ID - Silver2020 ER -