TY  - JOUR
AU  - Ofek, Lia
AU  - Goder, Daniella
AU  - Zilberman, Meital
PY  - 2019
DA  - 2019/10/11
TI  - Formulation-Properties of Novel Ibuprofen-Loaded Soy Protein Wound Dressings
JO  - Recent Progress in Materials
SP  - 004
VL  - 01
IS  - 04
AB  - Background: Wound management is an important field in medical care, as annually, millions of wounds require treatment worldwide. Soy protein is highly biocompatible, easily processed, and a relatively cheap natural polymer, which can be used for wound dressing applications.

Methods: In this study, solvent cast soy protein films, plasticized by glycerol and cross-linked by glyoxal, were thermally treated and their mechanical properties were evaluated as a function of various processing parameters. Samples were then loaded with ibuprofen, an analgesi c, and their drug release profiles were assessed.

Results: Cross-linking and plasticizing were found to be essential for high mechanical strength while maintaining sufficient flexibility. Higher treatment temperature and longer duration of treatment resulted in higher tensile strength and Young’s modulus, and lower tensile strain, while higher concentrations of glycerol had the opposite effect. Release profiles of ibuprofen from the films exhibited a medium burst release of 71–83% in the initial 6 h, followed by a decline in the release rate. The glycerol content practically did not affect the drug release profile.

Conclusions: Our research shows that the novel soy protein-based films have a high potential in providing immediate pain relief after injury concomitantly exhibiting adequate tensile properties, and therefore are promising for wound coverage applications.
SN  - 2689-5846
UR  - https://doi.org/10.21926/rpm.1904004
DO  - 10.21926/rpm.1904004
ID  - Ofek2019
ER  -