TY  - JOUR
AU  - Khosravi, Mohsen
PY  - 2026
DA  - 2026/01/26
TI  - Optimizing Psychopharmacotherapy Using Personality Biomarkers: A Seven-Factor Model Perspective
JO  - OBM Neurobiology
SP  - 320
VL  - 10
IS  - 01
AB  - Personalized psychopharmacotherapy remains a critical yet underdeveloped frontier in psychiatry, as traditional approaches often fail to address substantial interindividual variability in drug efficacy and tolerability. While demographic, clinical, and genetic factors have improved treatment precision, they do not fully account for observed heterogeneity. Recent advances highlight the promise of personality traits, particularly as operationalized by Cloninger’s Seven-Factor Model, as novel biomarkers for treatment optimization. This model distinguishes between temperament—biologically-based, heritable predispositions—and character, which is shaped by environmental, developmental, and cultural factors. Mapping these dimensions to neurochemical pathways offers a framework for tailoring pharmacological interventions to individual neurobiological profiles, potentially enhancing symptom control, tolerability, and adherence. Integrating personality assessment with pharmacogenomics, neuroimaging, and computational phenotyping may enable more holistic patient stratification, fostering the development of precision psychiatry. However, significant methodological, practical, and ethical challenges persist, including inconsistent findings, concerns regarding validity and generalizability, and the risk of stigmatization or misuse of sensitive data. Future research should prioritize large-scale, diverse, and longitudinal studies that leverage advances in artificial intelligence and integrative biomarker platforms. Interdisciplinary collaboration and rigorous ethical oversight are essential to translate the theoretical promise of personality-informed psychopharmacotherapy into effective, equitable, and patient-centered clinical practice. Ultimately, incorporating personality biomarkers may redefine the landscape of individualized psychiatric care and advance the goals of precision psychiatry.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.2601320
DO  - 10.21926/obm.neurobiol.2601320
ID  - Khosravi2026
ER  -