TY  - JOUR
AU  - Ismail, Che Aishah Nazariah
AU  - Shafin, Nazlahshaniza
AU  - Azman, Khairunnuur Fairuz
AU  - Long, Idris
AU  - Yaakob, Nor Syafinaz
PY  - 2025
DA  - 2025/04/09
TI  - Unraveling the Involvement of Serotonergic 5-Hydroxytryptamine Receptor-6 Activation in Chronic Pain: A Narrative Review
JO  - OBM Neurobiology
SP  - 283
VL  - 09
IS  - 02
AB  - Chronic pain is a significant and global healthcare issue that hugely implies the quality of life and productivity of the affected individuals. It is challenging to treat and thus necessitates a deeper understanding of its underlying pathomechanisms to develop targeted interventions. Serotonin is one of the essential neurotransmitters involved in the propagation of pain signals through both ascending and descending pathways, acting via various receptor subtypes, including the 5-hydroxytryptamine receptor-6 (5-HT6R). Recent studies have shed light on the involvement of 5-HT6R in the pathophysiology of chronic pain. This review aimed to uncover the emerging roles of 5-HT6R in chronic pain research by focusing on its functions in pain modulation, neuronal excitability, and pain processing. Although 5-HT6R has been recently discovered, previous studies have revealed its therapeutic effects in modulating chronic pain. Understanding the precise mechanism underlying the 5-HT6R may offer new avenues for future strategies of chronic pain management and indirectly improve the individual’s quality of life. However, further research is warranted to elucidate the intricate interplay between 5-HT6R and other pain modulatory pathways, paving the way for more effective and tailored therapeutic strategies for chronic pain.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.2502283
DO  - 10.21926/obm.neurobiol.2502283
ID  - Ismail2025
ER  -