TY  - JOUR
AU  - Newburn, Gil
AU  - McGeown, Joshua
AU  - Kwon, Eryn
AU  - Tayebi, Maryam
AU  - Condron, Paul
AU  - Emsden, Taylor
AU  - Holdsworth, Samantha
AU  - Cornfeld, Daniel
AU  - Bydder, Graeme
PY  - 2023
DA  - 2023/12/14
TI  - Targeted MRI (tMRI) of Small Increases in the T<sub>1</sub> of Normal Appearing White Matter in Mild Traumatic Brain Injury (mTBI) Using a Divided Subtracted Inversion Recovery (dSIR) Sequence
JO  - OBM Neurobiology
SP  - 201
VL  - 07
IS  - 04
AB  - In modelling studies targeted MRI (tMRI) of small increases in the T1 of tissues using divided Subtracted Inversion Recovery (dSIR) sequences show ten or more times the contrast seen with conventional IR sequences. This may be particularly useful in imaging normal appearing white matter where there may be small changes in T1 and/or T2 in disease but these changes may be insufficient to produce useful contrast with conventional T2-weighted spin echo (T2-wSE) and T2-FLuid Attenuated Inversion Recovery (T2-FLAIR) sequences. In a case of recurrent mild Traumatic Brain Injury (mTBI), very extensive high contrast abnormalities were seen in white matter using a dSIR sequence that targeted small increases in T1 in areas where no abnormality was apparent with T2-wSE or T2-FLAIR sequences. The increases in T1 may be due to neuroinflammation and/or degeneration which produces the abnormalities seen on the dSIR images. tMRI of normal appearing white matter may have widespread application in clinical MRI of the brain. 
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.2304201
DO  - 10.21926/obm.neurobiol.2304201
ID  - Newburn2023
ER  -