TY  - JOUR
AU  - Sahakyan, Naira
AU  - Petrosyan, Margarit
PY  - 2022
DA  - 2022/10/08
TI  - Possible Preventive Effect of <i>Ziziphora clinopodioides</i> Lam. Essential Oil on Some Neurodegenerative Disorders
JO  - OBM Neurobiology
SP  - 140
VL  - 06
IS  - 04
AB  - The present article describes some characteristics of the effect of essential oil (EO) extracted from Ziziphora clinopodioides harvested from Armenian highlands on microglial cell lines (BV-2 wild-type (WT) and acyl-CoA oxidase1 (ACOX1)-deficient (Acox1–/–) cells). The mutant cell line was used as a model to investigate cellular oxidative damage following EO treatment. The main components of the tested EO were pulegone, isomenthone, 1,8-cineole, piperitone, and neomenthole, with concentrations of 42.1%, 9.7%, 8.22%, 7.35%, and 5.9%, respectively, in plants harvested from the high-altitude Armenian landscape. The IC50 value of the EO in the DPPH assay was 7.025 µL/mL. The sub-cytotoxic concentrations (based on the MTT assay) for both cell lines were 5 × 10–1 µL/mL. The catalase activity of the WT cells was decreased following 24-h treatment with the EO, but that of Acox1–/– BV-2 cellswas increased. ACOX1 activity was decreased (up to 49%) at 72hof treatment. These results show the protective effect of the tested EO on Acox1–/– mutantcells.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.2204140
DO  - 10.21926/obm.neurobiol.2204140
ID  - Sahakyan2022
ER  -