TY  - JOUR
AU  - Brown, Joshua
AU  - Broadway, Jessica
PY  - 2021
DA  - 2021/04/20
TI  - Lamotrigine-Associated Progressive Dysphasia and Cognitive Dysfunction
JO  - OBM Neurobiology
SP  - 091
VL  - 05
IS  - 02
AB  - Lamotrigine is generally accepted as a well-tolerated medication with few cognitive side effects.  Here, we report a case of a 62-year old female with a severe, rapidly progressive dementia-like process which was completely reversed after reduction of lamotrigine.  Associated findings included hyperreflexia with clonus, ataxia, Wernicke-like aphasia, global cognitive impairment, burst suppression on electroencephalogram (EEG), and bilateral parietal hypo-metabolism on fluorodeoxyglucose-Positron Emission Tomography (FDG-PET).  To our knowledge, this is the first case of a severe neuropsychiatric syndrome attributed to lamotrigine at the Food and Drug administration (FDA) recommended dose and not associated with epileptic activity.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.2102091
DO  - 10.21926/obm.neurobiol.2102091
ID  - Brown2021
ER  -