TY  - JOUR
AU  - Geraedts, Joep
PY  - 2021
DA  - 2021/01/28
TI  - Prenatal and Preimplantation Genetic Diagnosis of Huntington's Disease
JO  - OBM Neurobiology
SP  - 085
VL  - 05
IS  - 01
AB  - Huntington’s disease (HD) is an autosomal dominant disease that immensely impacts the affected families. However, the transmission of the disease from carriers to their offspring could be prevented. Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are the only two available reproductive options for the carriers at risk to have disease-free children. PND for HD could be done through two kinds of genetic testing: direct and indirect. The same approaches are available for preimplantation genetic testing. In addition, a third alternative is nondisclosure testing, which is only available in the case of PGD. The pros and cons of different approaches are discussed. However, only a relatively few at-risk parents opt for PND and PGD. Furthermore, compared to PND, PGD is even more seldom opted for as a reproductive option.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.2101085
DO  - 10.21926/obm.neurobiol.2101085
ID  - Geraedts2021
ER  -