TY  - JOUR
AU  - Satrom, Katherine
AU  - Gisslen, Tate
AU  - Rao, Raghavendra
PY  - 2019
DA  - 2019/08/29
TI  - Hyperglycemia-Induced Brain Injury in Preterm Infants
JO  - OBM Neurobiology
SP  - 038
VL  - 03
IS  - 03
AB  - Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white matter content, abnormal synaptogenesis, microgliosis, and functional deficits in the absence of intraventricular hemorrhage. Data suggest that oxidative stress, inflammation, and abnormal substrate metabolism are responsible for these effects.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.1903038
DO  - 10.21926/obm.neurobiol.1903038
ID  - Satrom2019
ER  -