TY  - JOUR
AU  - Periasamy, Srinivasan
AU  - Chien, Se-Ping
AU  - Lee, Bing-Fang
AU  - Hsu, Dur-Zong
AU  - Liu, Ming-Yie
PY  - 2019
DA  - 2019/07/17
TI  - Melatonin Aggravated Oxaliplatin-Mimicking Sinusoidal Obstruction Syndrome: Role of Platelet Aggregation and Oxidative Stress
JO  - OBM Neurobiology
SP  - 033
VL  - 03
IS  - 03
AB  - (1) Background: Sinusoidal obstruction syndrome is a liver injury induced either by accidental ingestion of pyrrolizidine alkaloid monocrotaline or by chemotherapeutic drug oxaliplatin used for the treatment of colorectal cancer. Sinusoidal obstruction syndrome is characterized by rounding and swelling of the sinusoidal endothelial cell, which leads to obstruction of blood vessels, leukocyte infiltration and oxidative stress. Melatonin, a powerful antioxidant, prevents acute liver injury. We investigated the effect of melatonin on monocrotaline-induced sinusoidal obstruction syndrome in mice.
(2) Methods: Male C57BL/6JNarl mice were injected with a single dose (500 mg/kg) of monocrotaline to induce sinusoidal obstruction syndrome. Melatonin (1-30 mg/kg) was injected 1 h before monocrotaline treatment. After 24 h of monocrotaline treatment, mice were sacrificed. Hepatic collagen, oxidative stress, antioxidant activity, and the expression of apoptosis protein were measured.
(3) Results: Melatonin aggravated monocrotaline-induced sinusoidal obstruction syndrome. In addition, it not only increased serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, neutrophil count, histological score, hepatic platelet aggregation, oxidative stress, and activated apoptosis signaling pathway, but also decreased red blood cell count, hematocrit ratio, platelet count, lymphocyte count, hepatic collagen, and antioxidant activity.
(4) Conclusions: To conclude, melatonin aggravated monocrotaline-induced sinusoidal obstruction syndrome via hepatic platelet aggregation and oxidative stress, ultimately leading to activation of apoptosis.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.1903033
DO  - 10.21926/obm.neurobiol.1903033
ID  - Periasamy2019
ER  -