TY  - JOUR
AU  - Goyal, Daniel
AU  - Mansab, Fatma
AU  - Neil, James
AU  - Miyan, Jaleel
PY  - 2019
DA  - 2019/06/28
TI  - Autonomic Function Correlates with Microflora Compositions in a Small Cohort of Patients with Autism Spectrum Disorder: Preliminary Clinical Data and Discussion
JO  - OBM Neurobiology
SP  - 031
VL  - 03
IS  - 02
AB  - Research into the effects of microflora on health and in disease has increased recently.  Such enthusiasm seems well placed.  Should the preliminary studies translate through the larger, more powerful studies, the medical community may well have an entirely new platform from which to intervene for health and against disease.   Delineating the pathways involved in the microflora and host interaction is likely to yield further avenues for intervention.
Here we examine autonomic function and correlate this to compositional stool analysis (via qPCR) in 11 children with autism.  Results show that there is a significant correlation between vagal tone and the proportion of firmicutes in the stools of patients with autism (Spearman’s Ro = 0.782, p = 0.004, n = 11).  These preliminary results suggest there is a direct effect of microflora on neurological function in patients with autism.  More powerful studies are required to advance this promising field further.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.1902031
DO  - 10.21926/obm.neurobiol.1902031
ID  - Goyal2019
ER  -