TY  - JOUR
AU  - Loprinzi, Paul
PY  - 2019
DA  - 2019/05/10
TI  - The Effects of Exercise on Long-Term Potentiation: A Candidate Mechanism of the Exercise-Memory Relationship
JO  - OBM Neurobiology
SP  - 026
VL  - 03
IS  - 02
AB  - Objective: The objective of this paper was to evaluate the extent to which exercise may influence long-term potentiation (LTP), a key cellular correlate of episodic memory function. Methods: Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus and Google Scholar. Results: The computerized searches revealed 20 articles meeting the study criteria. Among these 20 evaluated articles, 17 were conducted in an animal model and 3 among humans. All 17 of these studies, with the exception of one, provided evidence that exercise enhances LTP. Each of the three human studies demonstrated evidence that exercise was favorably associated with LTP or LTP-like mechanisms. In animal models, exercise reliability increases LTP and lowers the threshold for LTP induction. Conclusion: Chronic exercise appears to robustly enhance LTP. The mechanisms of this effect are multifold and include, for example, exercise modulation of the structure and function of NMDA receptors.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.1902026
DO  - 10.21926/obm.neurobiol.1902026
ID  - Loprinzi2019
ER  -